Results 131 to 140 of about 90,229,355 (301)
Genetic Etiologies of Dystonia with Anarthria/Aphonia
Movement Disorders Clinical Practice, EarlyView.Abstract Background Dystonia with anarthria and/or aphonia (DAnAp) represents a distinctive phenotype manifesting across lifespan. Frequently associated with genetic disorders, early recognition is critical for diagnosis and management. Objectives To provide practical recommendations for the clinical evaluation of patients with DAnAp, enhancing ...
Anika Ménétrey +7 more
wiley +1 more source
Organoid Coculture Models for Cancer Research and Immunotherapy
Med Research, EarlyView.This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang +9 more
wiley +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Nutritional management is fundamental in Prader–Willi syndrome (PWS), but longitudinal data from routine pediatric practice are limited. We describe a 3‐year nutritional follow‐up of a boy with PWS complicated by obesity, insulin resistance, dyslipidemia, hyperuricemia, and fatty liver.
Peipei Chen, Hui Pan, Wei Chen
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee +2 more
wiley +1 more source
Polymer International, EarlyView.An overview and categorization of man‐made per‐ or polyfluoroalkyl substances (PFASs) including low‐molar‐mass and high‐molar‐mass fluorochemicals, and their international regulations is presented. Though certain PFASs are toxic, bioaccumulative and cross the human cellular membranes, others, such as fluoropolymers, are safe, reliable and involved in ...
Bruno Améduri
wiley +1 more source
Precision Medical Sciences, EarlyView.Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang +7 more
wiley +1 more source
Clinical Case ReportsThyroid hormone resistance (RTH) is a rare genetic disorder characterized by diminished responsiveness of target tissues to thyroid hormones, primarily due to mutations in the thyroid hormone receptor‐beta (TR‐β) gene.
Ahmad Al‐Bitar +3 more
doaj +1 more source
Role of Thyroid Hormones in Fishes [PDF]
, 2013 Literature review is devoted to analysis of role of thyroid hormones in fishes. Structural features of secretory epithelium and neuro-endocrine control of thyroid status in fishes are described.
Kutia, S.A. +3 more
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Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential
Phytotherapy Research, EarlyView.Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi +5 more
wiley +1 more source
Фактори експериментальної еволюції організмів, 2015 Aims. The human DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) protects cells against mutations and cell death. On the other hand, it causes the resistance of cancer cells to alkylating chemotherapy.
З. М. Нідоєва +4 more
doaj