Results 241 to 250 of about 86,799,447 (290)
Some of the next articles are maybe not open access.
Pituitary Resistance to Thyroid Hormones
Hormone Research, 2008Pituitary thyroid hormone resistance (PRTH) refers to a particular form of thyroid hormone refractoriness that is accompanied by peripheral hyperthyroidism, as only the TSH-secreting pituitary cells appear to be resistant to the effects of thyroid hormones. The presence of PRTH is suspected and diagnosed on the basis of the finding of high free thyroid
P, Beck-Peccoz +6 more
openaire +2 more sources
Familial thyroid hormone resistance
The American Journal of Medicine, 1981Eight patients with thyroid hormone resistance were found in four generations of a kindred containing 19 members. Results of studies in this family are consistent with an autosomal dominant mode of inheritance for this disorder. The affected family members were clinically euthyroid but all had goiters and markedly increased serum thyroid hormone levels:
M H, Brooks +5 more
openaire +2 more sources
Thyroid Hormone Generalized Resistance
Hormone Research, 2008The syndromes of thyroid hormone resistance may affect overall or only some tissues. The generalized resistance is an inherited disease which involves a familial eumetabolic or hypometabolic goiter, increased free thyroid hormones with normal or elevated plasma TSH levels; children may present mental retardation, deafness, short stature and delayed ...
C, Jaffiol +3 more
openaire +2 more sources
2014
Resistance to thyroid hormone (RTH) or thyroid hormone action defect (THAD) is the most frequent form of syndromes of reduced sensitivity to thyroid hormone. It is characterized by variable tissue hyposensitivity to thyroid hormone. RTHβ (formerly only RTH) is caused by mutations in the thyroid hormone receptor β gene (THRB).
Kazumichi, Onigata, Gabor, Szinnai
openaire +2 more sources
Resistance to thyroid hormone (RTH) or thyroid hormone action defect (THAD) is the most frequent form of syndromes of reduced sensitivity to thyroid hormone. It is characterized by variable tissue hyposensitivity to thyroid hormone. RTHβ (formerly only RTH) is caused by mutations in the thyroid hormone receptor β gene (THRB).
Kazumichi, Onigata, Gabor, Szinnai
openaire +2 more sources
Familial thyroid hormone resistance
Metabolism, 1982Three phenotypically normal family members were discovered to have elevated thyroid function (T4, free T4, T3, 123I uptake), but were clinically euthyroid. Further evaluation of pituitary and peripheral indices of thyroid hormone action was consistent with the diagnosis of peripheral resistance to thyroid hormone.
D S, Cooper +5 more
openaire +2 more sources
Thyroid hormone resistance syndromes
The American Journal of Medicine, 1993The thyroid hormone resistance syndromes are disorders in which the body's tissues are resistant to the effects of thyroid hormone. Generalized resistance to thyroid hormone (GRTH) is characterized by resistance in the pituitary gland and in most or all of the peripheral tissues.
M T, McDermott, E C, Ridgway
openaire +2 more sources
2021
Resistance to Thyroid hormone beta (RTH-β) is a genetic syndrome characterized by impaired peripheral sensitivity to thyroid hormone (TH) due to heterozygous dominant-negative variants in the THRB gene, coding for TH receptor beta (TRβ).
Luca Persani, Irene Campi
openaire +1 more source
Resistance to Thyroid hormone beta (RTH-β) is a genetic syndrome characterized by impaired peripheral sensitivity to thyroid hormone (TH) due to heterozygous dominant-negative variants in the THRB gene, coding for TH receptor beta (TRβ).
Luca Persani, Irene Campi
openaire +1 more source
Syndromes of thyroid hormone resistance
Annales d'Endocrinologie, 2005Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in the presence of measurable serum TSH concentrations. About 85% of patients with RTH are harboring mutations in thyroid hormone receptor beta (TRB). These mutations cluster in
P. Beck-Peccoz, D. Mannavola, L.Persani
openaire +3 more sources
Clinics in Laboratory Medicine, 1993
Resistance to thyroid hormone encompasses a clinically heterogeneous group of conditions characterized by reduced responses of target tissues to a supply of thyroid hormone that under normal circumstances would be excessive. The syndrome of resistance to thyroid hormone is first suspected when serum thyroid hormone levels are found to be elevated in ...
openaire +4 more sources
Resistance to thyroid hormone encompasses a clinically heterogeneous group of conditions characterized by reduced responses of target tissues to a supply of thyroid hormone that under normal circumstances would be excessive. The syndrome of resistance to thyroid hormone is first suspected when serum thyroid hormone levels are found to be elevated in ...
openaire +4 more sources
The Syndromes of Resistance to Thyroid Hormone*
Endocrine Reviews, 1993I. Introduction THE syndromes of resistance to thyroid hormone are characterized by reduced clinical and biochemical manifestations of thyroid hormone action relative to the circulating hormone levels. In practice, most patients are identified by the persistent elevation of serum levels of T4 and T3 with “inappropriately” nonsuppressed TSH, in the ...
S, Refetoff, R E, Weiss, S J, Usala
openaire +2 more sources