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Syndromes of thyroid hormone resistance
Resistance to the action of thyroid hormone can involve both peripheral tissues and the pituitary (global resistance), the pituitary only or peripheral tissues alone. Global resistance is of variable severity and has been observed in more than 60 individuals, the majority occurring in 17 families.
S. Refetoff
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Hormone Research, 2009
Resistance to thyroid hormone (RTH) is usually dominantly inherited and is characterized by elevated free thyroid hormones in the serum and failure to suppress pituitary thyroid stimulating hormone (TSH) secretion with variable refractoriness to hormone action in peripheral tissues.
Christian G. Bien +79 more
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Resistance to thyroid hormone (RTH) is usually dominantly inherited and is characterized by elevated free thyroid hormones in the serum and failure to suppress pituitary thyroid stimulating hormone (TSH) secretion with variable refractoriness to hormone action in peripheral tissues.
Christian G. Bien +79 more
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Postgraduate Medical Journal, 2008
Abstract Thyroid hormone resistance (THR) is a rare syndrome of reduced end organ sensitivity. Patients with THR have elevated serum free thyroxine (FT4), free triiodothyronine (FT3), but normal or slightly elevated serum thyrotropin values.
N K, Agrawal +4 more
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Abstract Thyroid hormone resistance (THR) is a rare syndrome of reduced end organ sensitivity. Patients with THR have elevated serum free thyroxine (FT4), free triiodothyronine (FT3), but normal or slightly elevated serum thyrotropin values.
N K, Agrawal +4 more
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Annual Review of Medicine, 1992
Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid ...
R E, Weiss, S, Refetoff
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Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid ...
R E, Weiss, S, Refetoff
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2006
Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited syndrome of reduced end-organ responsiveness to thyroid hormone. Patients with RTH have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level.
Tolulope O, Olateju +1 more
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Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited syndrome of reduced end-organ responsiveness to thyroid hormone. Patients with RTH have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level.
Tolulope O, Olateju +1 more
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Reviews in Endocrine and Metabolic Disorders, 2000
The syndromes of resistance to thyroid hormone (RTH) are generally characterized by reduced tissue responsiveness to thyroid hormone (TH) despite elevated circulating levels of free T 3 and/or T 4 (Refetoff et al., 1993). It is associated with an inappropriately normal or raised serum TSH characteristic of impaired thyrotroph sensitivity.
R E, Weiss, S, Refetoff
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The syndromes of resistance to thyroid hormone (RTH) are generally characterized by reduced tissue responsiveness to thyroid hormone (TH) despite elevated circulating levels of free T 3 and/or T 4 (Refetoff et al., 1993). It is associated with an inappropriately normal or raised serum TSH characteristic of impaired thyrotroph sensitivity.
R E, Weiss, S, Refetoff
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Resistance to Thyroid Hormone in Pregnancy
Obstetrics & Gynecology, 2008Resistance to thyroid hormone manifests as high serum levels of free thyroxine and free triiodothyronine, with nonsuppressed thyroid stimulating hormone (TSH) levels. We report a case series of three patients with this condition, the changes in thyroid function tests during their pregnancies, and their obstetric outcome.Three pregnant women with ...
Simi, Dhingra +3 more
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Pituitary Resistance to Thyroid Hormones
Hormone Research, 2008Pituitary thyroid hormone resistance (PRTH) refers to a particular form of thyroid hormone refractoriness that is accompanied by peripheral hyperthyroidism, as only the TSH-secreting pituitary cells appear to be resistant to the effects of thyroid hormones. The presence of PRTH is suspected and diagnosed on the basis of the finding of high free thyroid
P, Beck-Peccoz +6 more
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