Results 41 to 50 of about 1,415,742 (343)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Within-individual design for assessing true individual responses in resistance training-induced muscle hypertrophy

Frontiers in Sports and Active Living
Understanding interindividual variability in muscle hypertrophy in response to resistance training (RT) is a key focus of contemporary research. Common aims include identifying determinants of variability and recognizing individuals who do not respond to
Talisson Santos Chaves, Deivid Gomes da Silva, Manoel Emílio Lixandrão, Cleiton Augusto Libardi   +3 more
doaj   +1 more source

Autoregulation in Resistance Training: Addressing the Inconsistencies [PDF]

Sports Medicine, 2020
AbstractAutoregulation is a process that is used to manipulate training based primarily on the measurement of an individual’s performance or their perceived capability to perform. Despite being established as a training framework since the 1940s, there has been limited systematic research investigating its broad utility.
Ben Hayden Stephens Hemingway, Paul Swinton, Leon Greig, Paul Comfort, Paul Comfort, Paul Comfort, Kay Cooper, Rodrigo R. Aspe   +7 more
openaire   +5 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Residual Impact of Concurrent, Resistance, and High-Intensity Interval Training on Fasting Measures of Glucose Metabolism in Women With Insulin Resistance

Frontiers in Physiology, 2021
We sought to assess the residual effects (post 72-h training cessation) on fasting plasma glucose (FPG) and fasting insulin (FI) after 12-weeks of high-intensity interval training (HIIT), resistance training (RT), or concurrent training (CT) in women ...
Cristian Alvarez, Emmanuel Gomes Ciolac, Guilherme Veiga Guimarães, David C Andrade, Manuel Vasquez-Muñoz, Matías Monsalves-Álvarez, Matías Monsalves-Álvarez, Pedro Delgado-Floody, Alicia M. Alonso-Martínez, Mikel Izquierdo, Mikel Izquierdo   +10 more
doaj   +1 more source

Robotic Resistance Treadmill Training Improves Locomotor Function in Children With Cerebral Palsy: A Randomized Controlled Pilot Study [PDF]

, 2017
Objective To determine whether applying controlled resistance forces to the legs during the swing phase of gait may improve the efficacy of treadmill training as compared with applying controlled assistance forces in children with cerebral palsy (CP ...
Arora, Pooja, Gaebler-Spira, Deborah J., Kim, Janis, Schmit, Brian D., Wu, Ming   +4 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment

Frontiers in Pharmacology
The all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill.
Wanting Chen, Wanting Chen, Preeti Pandey, Zyta M. Ziora, Zyta M. Ziora, Anjana Jayasree, Anjana Jayasree, Harendra S. Parekh, Harendra S. Parekh   +8 more
doaj   +1 more source

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training [PDF]

, 2008
Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Cribb, Paul J, Hayes, Alan
core   +1 more source