Results 201 to 210 of about 32,295 (302)

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

Restoration of Excitation‐Inhibition Balance and Improvement of Schizophrenia‐like Behavioral Deficits via Electroacupuncture

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Ablation of nNos from Erbb4‐positive neurons induces impaired GABAergic transmission and disruption of excitatory and inhibitory balance, which further cause hyperactivity of pyramidal neurons, resulting in schizophrenia‐relevant behavioral deficits. EA treatment rescues decreased GABAergic transmission and restores excitatory and inhibitory balance by
Chaofan Wan, Yucen Xia, Jinglan Yan, Weipeng Lin, Yuanjia Zheng, Yiqiu Lin, Lin Yao, Yongjun Chen   +7 more
wiley   +1 more source

Cutaneous Small Vessel Vasculitis Secondary to Clozapine Use in a 22-Year-Old Man With Treatment-Resistant Schizophrenia. [PDF]

Cureus
Ravindran KO, Kapil V V, Madhavan K, Somasundaram RO.   +3 more
europepmc   +1 more source

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Commentary: Real-world effectiveness and safety of xanomeline and trospium for treatment-resistant schizophrenia in a state hospital system. [PDF]

Front Psychiatry
Price MZ, Price RL.
europepmc   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

From Signal to Symptom: EEG Paroxysms and Background Slowing as Potential Biomarkers and Compensatory Failures in Treatment-Resistant Schizophrenia. [PDF]

Biomedicines
Panov G, Panova P, Dyulgerova S, Chakarov I.   +3 more
europepmc   +1 more source

Differential Responsiveness to Exercise and Cognitive Remediation in Physical Health in People With Schizophrenia: Results From the CORTEX‐SP Study

European Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT Non‐pharmacological interventions, such as exercise and cognitive remediation, have been widely investigated in people with schizophrenia (SZ), showing beneficial effects and supporting their role as complementary approaches to pharmacological treatment.
Mikel Tous‐Espelosin, Nagore Iriarte‐Yoller, Agurne Sampedro, Iker Lasa‐Sagaseta, Cristóbal Pavon, Natalia Ojeda, Pedro Sanchez, Javier Peña, Sara Maldonado‐Martín   +8 more
wiley   +1 more source

Empowerment-based case management for treatment-resistant schizophrenia: a three-year single case report. [PDF]

Front Psychiatry
Wang C, Li X, Chen J, Li X, Hou W, Dong N.   +5 more
europepmc   +1 more source