Results 71 to 80 of about 608,135 (288)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

UNICONE PLUS VS. UNICONE - IN VITRO CYCLIC FATIGUE STUDY AT DIFFERENT ENVIROMENTAL TEMPERATURES

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2020
Introduction, aim: The issue of fracture of endodontic nickel-titanium instruments is quite extensive. It is an alloy that has the ability to change its internal structure.
A. Jusku   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Reflextions on itinerant education on EJA: report of a specialist teacher

open access: yesRevista Educação Especial, 2010
This paper has the objective to analyse and reflect on the performance of the itinerant teacher who works with students with intellectual disabilities at Education of young and adults.
Annie Gomes Redig
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Literature Review: Mekanisme Resistensi Kemoterapi Berbasis Platinum

open access: yesJurnal Kesehatan, 2020
Cisplatin is a type of platinum-based chemotherapy that is often used in the spectrum of solid neoplasms, including the ovaries, testicles, urinary vesicles, colorectal, lungs, and head-neck.
Amelia Rizky Khalidah
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Tre processi “scomodi” [PDF]

open access: yesDiacronie. Studi di Storia Contemporanea, 2014
This paper aims to analyze the role and the pattern of the militant lawyering of Leonida Casali, one of the leading members of Bologna section of the Italian Communist Party and of the Democratic Solidarity Committee during the postwar period.
Greta Fedele
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Resistance of nosocomial strains to antibacterial drugs and its link to biofilm formation

open access: yesRegulatory Mechanisms in Biosystems, 2017
The problem of nosocomial infections is considered in connection with more frequent formation and wide distribution in clinical practice of new strains of hospital bacteria that have a cross-resistence to antibacterial drugs.
T. V. Sklyar   +4 more
doaj   +1 more source

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