Results 91 to 100 of about 19,820 (248)

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants [PDF]

, 2018
Objectives: In 2014 probiotic supplementation (Lactobacillus acidophilus and Bifidobacterium longum subspecies infantis; Infloran®) was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway.
Pedersen, Tanja, Willassen, Nils Peder, Esaiassen, Eirin, Rettedal, Siren, Støen, Ragnhild, Hjerde, Erik, Nakstad, Britt, Klingenberg, Claus, Cavanagh, Jorunn Pauline, Andresen, Jannicke Hanne, Jorunn Pauline Cavanagh, Jannicke H. Andresen, Ragnhild Støen, Claus Klingenberg, Erik Hjerde, Britt Nakstad, Siren I. Rettedal, Eirin Esaiassen, Tanja Pedersen, Nils P. Willassen   +19 more
core   +1 more source

Population-level impacts of antibiotic usage on the human gut microbiome

Nature Communications, 2023
Here, the authors study the population-level impact of antimicrobial resistance genes (ARGs). By analyzing 8972 metagenomes and 3,096 gut microbiomes from healthy individuals not taking antibiotics, they demonstrate significant correlations between both ...
Kihyun Lee, Sebastien Raguideau, Kimmo Sirén, Francesco Asnicar, Fabio Cumbo, Falk Hildebrand, Nicola Segata, Chang-Jun Cha, Christopher Quince   +8 more
doaj   +1 more source

Type IV‐Dominated Plasmid‐Encoded CRISPR‐Cas Systems Are Enriched in Multireplicon and Multi‐Stressor Resistance Plasmids Across the Global Plasmidome

Molecular Microbiology, EarlyView.
Screening 72,555 plasmid sequences reveals that intact CRISPR‐Cas systems are rare (1.03%) but strongly enriched in multireplicon and multi‐stressor resistance plasmids, with Type IV‐A as the dominant subtype. These findings implicate plasmid‐encoded CRISPR‐Cas as non‐randomly retained elements of structurally complex and high‐risk backbones.
Hannay Crystynah Almeida de Souza, Anamaria Mota Pereira dos Santos, Arlen Carvalho de Oliveira Almeida, Carlos Adam Conte Junior, Pedro Panzenhagen   +4 more
wiley   +1 more source

Mining the Antibiotic Resistome

Chemistry & Biology, 2012
Antibiotic-producing microoganisms are a reservoir of drug resistance genes. Studies of the "antibiotic resistome" can inform antimicrobial drug discovery and explain the emergence of multidrug resistant pathogens. In this issue of Chemistry & Biology, Westman and colleagues take an alternative look at the resistome and identify genes that could be ...
openaire   +2 more sources

The Neglected Intrinsic Resistome of Bacterial Pathogens

PLoS ONE, 2008
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows ...
Fajardo, Alicia, Martinez-Martin, Nadia, Mercadillo, Maria, Galan, Juan, Ghysels, Bart, Matthijs, Sandra, Cornelis, Pierre, Wiehlmann, Lutz, Tümmler, Burkhard, Baquero, Fernando, Martinez, Jose Luis   +10 more
openaire   +7 more sources

Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome

Nature Communications
The assembly of the gut resistome in early life is key to infant health. Specific perinatal factors such as cesarean section (C-section), antibiotic exposure and lack of breastfeeding practices are detrimental to proper microbial development and increase
Anna Samarra, Alejandro J. Alcañiz, C. Martínez-Costa, A. Marina, I. Comas, N. Segata, N. Quijada, M. C. Collado   +7 more
semanticscholar   +1 more source

Protocol for the Therapy Personalisation Using Multiomic Analyses in Inflammatory Bowel Disease (THAMES‐IBD) Study

JCC Plus, Volume 1, Issue 6, November 2026.
ABSTRACT Background Despite an expanding repertoire of advanced therapies for inflammatory bowel disease (IBD), treatment outcomes remain suboptimal, with only 30%–40% of patients achieving sustained remission. Emerging evidence indicates that therapeutic outcomes are shaped by complex interactions between host immune pathways, the gut microbiome and ...
John P. Thomas, Aamir Saifuddin, Sadek Malas, Meztli Matadamas Guzman, Cristina Di Poto, Dimple Dixit, Isabel Laszczak, H. Sophia Chung, Erik L. Allman, Yang Song, James L. Alexander, Bat‐Erdene Jugder, Ailsa Hart, Kyle Bednar, Nick Powell   +14 more
wiley   +1 more source

Geographic patterns and determinants of antibiotic resistomes in coastal sediments across complex ecological gradients

Frontiers in Microbiology, 2022
Coastal areas are highly influenced by terrestrial runoffs and anthropogenic disturbances, commonly leading to ecological gradients from bay, nearshore, to offshore areas.
Shangling Xiong, Shangling Xiong, Kai Wang, Kai Wang, Kai Wang, Huizhen Yan, Dandi Hou, Dandi Hou, Yanting Wang, Meng Li, Demin Zhang, Demin Zhang, Demin Zhang   +12 more
doaj   +1 more source

Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults

Cell Reports, 2022
SUMMARY Antibiotics are deployed against bacterial pathogens, but their targeting of conserved microbial processes means they also collaterally perturb the commensal microbiome.
Winston E. Anthony, Bin Wang, Kimberley V. Sukhum, Alaric W. D’Souza, T. Hink, Candice Cass, Sondra M. Seiler, K. Reske, Christopher Coon, E. Dubberke, C. Burnham, G. Dantas, Jennie H. Kwon   +12 more
semanticscholar   +1 more source