Results 81 to 90 of about 11,688 (211)

Population-level impacts of antibiotic usage on the human gut microbiome

Nature Communications, 2023
Here, the authors study the population-level impact of antimicrobial resistance genes (ARGs). By analyzing 8972 metagenomes and 3,096 gut microbiomes from healthy individuals not taking antibiotics, they demonstrate significant correlations between both ...
Kihyun Lee, Sebastien Raguideau, Kimmo Sirén, Francesco Asnicar, Fabio Cumbo, Falk Hildebrand, Nicola Segata, Chang-Jun Cha, Christopher Quince   +8 more
doaj   +1 more source

The association between early life antibiotic exposure and the gut resistome of young children: a systematic review

Gut Microbes, 2022
Antimicrobial resistance is a growing public health burden, but little is known about the effects of antibiotic exposure on the gut resistome. As childhood (0–5 years) represents a sensitive window of microbiome development and a time of relatively high ...
Rebecca M. Lebeaux, Despina B. Karalis, Jihyun Lee, Hanna C. Whitehouse, Juliette C. Madan, Margaret R. Karagas, Anne G. Hoen   +6 more
doaj   +1 more source

Systemic Antibiotics in the Surgical Treatment of Peri‐Implantitis: Impact on the Salivary Microbiome

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri‐implantitis. Materials and Methods A subset of 27 patients treated surgically for peri‐implantitis with an adjunctive 7‐day course of systemic antibiotics were ...
Caroline Riben Grundström, Bodil Lund, Nagihan Bostanci, Angelika Silbereisen, Alexandra Pennhag, Ina Schuppe Koistinen, Yinghua Zha, Anastasios Damdimopoulos, Georgios N. Belibasakis, Margareta Hultin   +9 more
wiley   +1 more source

The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs

Microbiome, 2022
Background Antimicrobials are used in food-producing animals for purposes of preventing, controlling, and/or treating infections. In swine, a major driver of antimicrobial use is porcine reproductive and respiratory syndrome (PRRS), which is caused by a ...
Tara N. Gaire, Carissa Odland, Bingzhou Zhang, Tui Ray, Enrique Doster, Joel Nerem, Scott Dee, Peter Davies, Noelle Noyes   +8 more
doaj   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

The Neglected Intrinsic Resistome of Bacterial Pathogens

PLoS ONE, 2008
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows ...
Fajardo, Alicia, Martinez-Martin, Nadia, Mercadillo, Maria, Galan, Juan, Ghysels, Bart, Matthijs, Sandra, Cornelis, Pierre, Wiehlmann, Lutz, Tümmler, Burkhard, Baquero, Fernando, Martinez, Jose Luis   +10 more
openaire   +7 more sources

Breastfeeding and the milk resistome shape the establishment and transmission of antibiotic resistance genes in the infant gut microbiome

Gut Microbes
The infant resistome, the collection of antibiotic resistance genes (ARGs) of newborns, is critical for gut microbiota establishment. Using metagenomic sequencing data, we analyzed various 1-week and 1-month postpartum samples to study infant resistome ...
Zhe Pan, Calum J. Walsh, Conor Feehily, Sai Ravi Chandra Nori, Fionnuala M. McAuliffe, Paul D. Cotter, John MacSharry, Douwe van Sinderen   +7 more
doaj   +1 more source

Mobilization of Antibiotic Resistance: Are Current Approaches for Colocalizing Resistomes and Mobilomes Useful?

Frontiers in Microbiology, 2020
Antimicrobial resistance (AMR) poses a global human and animal health threat, and predicting AMR persistence and transmission remains an intractable challenge.
Ilya B. Slizovskiy, Kingshuk Mukherjee, Christopher J. Dean, Christina Boucher, Noelle R. Noyes   +4 more
doaj   +1 more source

Moderate‐Temperature Hydrothermal Treatment Removes Detectable DNA and Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value

Water and Environment Journal, EarlyView.
This graphical abstract shows the overall study design where dewatered wastewater sludge samples were collected and subjected to a range of HT temperatures. Measurement of nucleic acid concentration and antibiotic resistance gene profiles across temperatures showed that HT at moderate temperatures offers sustainable, scalable sludge sanitation and ARG ...
R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge   +3 more
wiley   +1 more source

Leveraging the microbiome to combat antibiotic resistant gynecological infections

npj Antimicrobials and Resistance
The vaginal resistome can be considered a collection of the resistant determinants in the vaginal microbiome. Here we review the vaginal resistome including the microbes and resistant genes harbored in common gynecological infections, vaginal microbes ...
Tanya Kumar, Aryak Rekhi, Yumie Lee, Julielam Tran, Arlene Grace D. Nagtalon, Sidhant Rohatgi, Erika L. Cyphert   +6 more
doaj   +1 more source