Molecular Oncology, Volume 19, Issue 12, Page 3665-3684, December 2025.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Detection of Multi-drug Resistant \u3cem\u3eEscherichia coli\u3c/em\u3e in the Urban Waterways of Milwaukee, WI [PDF]
, 2015 Urban waterways represent a natural reservoir of antibiotic resistance which may provide a source of transferable genetic elements to human commensal bacteria and pathogens. The objective of this study was to evaluate antibiotic resistance of Escherichia
Ahuja, Neha H. +5 more
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Dissemination of antibiotic resistance genes from antibiotic producers to pathogens [PDF]
, 2017 It has been hypothesized that some antibiotic resistance genes (ARGs) found in pathogenic bacteria derive from antibiotic-producing actinobacteria. Here we provide bioinformatic and experimental evidence supporting this hypothesis.
Blin, Kai +8 more
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An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance [PDF]
, 2018 On June 20, 2017, members of the environmental engineering and science (EES) community convened at the Association of Environmental Engineering and Science Professors (AEESP) Biennial Conference for a workshop on antimicrobial resistance.
Alcalde, Reinaldo E. +25 more
core +1 more source
Biotechnological applications of functional metagenomics in the food and pharmaceutical industries [PDF]
, 2015 peer-reviewedMicroorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods.
Alvarez-Ordonez, Avelino +3 more
core +1 more source
Abundance and diversity of resistomes differ between healthy human oral cavities and gut
Nature Communications, 2020 Antimicrobial resistance (AMR) represents a global health threat. Here, the authors analyse the oral and gut resistomes from metagenomes of diverse populations and find that the oral resistome harbours higher abundance but lower diversity of ...
Victoria R. Carr +7 more
doaj +1 more source
Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs [PDF]
, 2013 Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past several decades, with far-reaching healthcare and societal costs.
Ahmadi, Sara +4 more
core +2 more sources
MicrobiologyOpen, Volume 14, Issue 6, December 2025.Next‐generation sequencing (NGS) is poised to transform infectious‐disease diagnostics. Falling per‐sample costs, new CPT codes and FDA pathways, and 24‐h, multiplexed resistome reports converge to deliver faster, evidence‐based therapy and stronger surveillance. Our roadmap links the economic, regulatory, and clinical pillars to accelerate routine NGS
John Osei Sekyere
wiley +1 more source
The effects of offshore petroleum exploitation on microbial community and antibiotic resistome of adjacent marine sediments [PDF]
, 2020 Jing Wang, Jiti Zhou
openalex +1 more source
Reducing healthcare-associated infections incidence by a probiotic-based sanitation system: A multicentre, prospective, intervention study [PDF]
, 2018 Healthcare Associated Infections (HAI) are a global concern, further threatened by the increasing drug resistance of HAI-associated pathogens. On the other hand, persistent contamination of hospital surfaces contributes to HAI transmission, and it is not
Alessandro Conte +15 more
core +3 more sources