Results 131 to 140 of about 44,432 (315)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Transition mechanisms in hypersonic wind-tunnel nozzles: a methodological approach using global linear stability analysis

Flow
Base-flow computations and stability analyses are performed for a hypersonic wind tunnel nozzle at a Mach number of 6. Isothermal and adiabatic wall boundary conditions are investigated, and moderate stagnation conditions are used to provide ...
Hugo Lemarquand, Mathieu Lugrin, Cédric Content, Clément Caillaud, Sébastien Esquieu, Denis Sipp   +5 more
doaj   +1 more source

An analysis on the approximate controllability of neutral impulsive stochastic integrodifferential inclusions via resolvent operators. [PDF]

Heliyon, 2023
Ma YK, Pradeesh J, Shukla A, Vijayakumar V, Jothimani K.   +4 more
europepmc   +1 more source

Expansion of the resolvent in a Feshbach model [PDF]

, 2019
Raffaele Carlone, Domenico Finco
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The resolvent cocycle in twisted cyclic cohomology and a local index formula for the Podles sphere [PDF]

, 2011
Adam Rennie, Roger Senior
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Spectrum and resolvent of multi-channel systems with internal energies and common boundary conditions

Қарағанды университетінің хабаршысы. Математика сериясы
In the article the spectrum and resolvent of the so-called multichannel systems with nonzero internal energies were investigated. The spectrum and resolvent of multichannel Sturm-Liouville systems with non-zero internal energies mi2 and general boundary
A.A. Valiyev, M.B. Valiyev, E.H. Huseynov   +2 more
doaj   +1 more source

Robustly Linearized Model Predictive Control for Nonlinear Infinite-Dimensional Systems. [PDF]

IFAC Pap OnLine, 2023
El-Kebir H, Berlin R, Bentsman J, Ornik M.   +3 more
europepmc   +1 more source