Results 101 to 110 of about 1,075,287 (378)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A complete classification of threshold properties for one-dimensional discrete Schr\"{o}dinger operators [PDF]

, 2013
We consider the discrete one-dimensional Schr\"{o}dinger operator $H=H_0+V$, where $(H_0x)[n]=-(x[n+1]+x[n-1]-2x[n])$ and $V$ is a self-adjoint operator on $\ell^2(\mathbb{Z})$ with a decay property given by $V$ extending to a compact operator from $\ell^
Ito, Kenichi, Jensen, Arne
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Asymptotic behaviour of mild solution of nonlinear stochastic partial functional equations

Nonlinear Analysis, 2019
This paper presents conditions to assure existence, uniqueness and stability for impulsive neutral stochastic integrodifferential equations with delay driven by Rosenblatt process and Poisson jumps.
Mamadou Abdoul Diop, Amour Toffodji Gbaguidi Amoussou, Carlos Ogouyandjou, Rathinasamy Sakthivel   +3 more
doaj   +1 more source

ON ITERATIVE CONVERGENCE OF RESOLVENTS OF ACCRETIVE OPERATORS

Demonstratio Mathematica, 2004
For solving the inclusion \(0 \in Ax\) for an accretive operator \(A\) on a real Banach space, the author considers iterations \(x_{n+1} = \alpha_n x_n + (1 - \alpha_n) y_n\), where \(y_n\) is an approximation of \((I + r A)^{-1}x_n\) in a given closed convex set. Weak and strong convergence results are proved and the method is applied to equations \(x
openaire   +2 more sources

Trace expansions for elliptic cone operators with stationary domains

, 2009
We analyze the behavior of the trace of the resolvent of an elliptic cone differential operator as the spectral parameter tends to infinity. The resolvent splits into two components, one associated with the minimal extension of the operator, and another,
Gil, Juan B., Krainer, Thomas, Mendoza, Gerardo A.   +2 more
core   +1 more source

Local elliptic regularity for solutions to stationary Fokker–Planck equations via Dirichlet forms and resolvents

Boundary Value Problems
In this paper, we show that, for a solution to the stationary Fokker–Planck equation with general coefficients, defined as a measure with an L 2 $L^{2}$ -density, this density not only exhibits H 1 , 2 $H^{1,2}$ -regularity but also Hölder continuity. To
Haesung Lee
doaj   +1 more source

Resolvent for Non-Self-Adjoint Differential Operator with Block-Triangular Operator Potential

Abstract and Applied Analysis, 2016
A resolvent for a non-self-adjoint differential operator with a block-triangular operator potential, increasing at infinity, is constructed. Sufficient conditions under which the spectrum is real and discrete are obtained.
Aleksandr Mikhailovich Kholkin
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Entanglement of a chiral scalar on the torus

Journal of High Energy Physics
We compute the entanglement entropy of an interval for a chiral scalar on a circle at an arbitrary temperature. We use the resolvent method, which involves expressing the entropy in terms of the resolvent of a certain operator, and we compute that ...
Nicolás Abate, David Blanco, Alan Garbarz, Mateo Koifman, Guillem Pérez-Nadal   +4 more
doaj   +1 more source