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Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2 [PDF]
Infection and Immunity, 2018 ABSTRACT Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD). CD is a persistent, lifelong infection affecting many organs, most notably the heart, where it may result in acute myocarditis and chronic cardiomyopathy. The pathological features include myocardial inflammation and fibrosis.
Anthony W Ashton +2 more
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Proceedings of the National Academy of Sciences, 2021
Significance The resolution of the acute inflammatory response is an active, highly organized process essential for tissue regeneration, wound healing, and the return to homeostasis that involves specialized proresolving mediators (SPMs). The elucidation of mediators that play roles in these processes is of general interest since
Ashley E. Shay +5 more
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Significance The resolution of the acute inflammatory response is an active, highly organized process essential for tissue regeneration, wound healing, and the return to homeostasis that involves specialized proresolving mediators (SPMs). The elucidation of mediators that play roles in these processes is of general interest since
Ashley E. Shay +5 more
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Total synthesis of resolvin D3
Organic & Biomolecular Chemistry, 2022Resolvin D3 was synthesized by the Suzuki–Miyaura cross-coupling reaction of C1–C8 borane with C9–C22 iodoolefin as the key reaction.
Narihito Ogawa +3 more
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Stereocontrolled total synthesis of Resolvin D4 and 17(R)-Resolvin D4
Organic & Biomolecular Chemistry, 2023We describe the stereocontrolled synthesis of Resolvin D4 and 17(R)-Resolvin D4. These molecules possess protective activities in resolving inflammation.
Robert Nshimiyimana +3 more
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Total Synthesis of Resolvin D5
The Journal of Organic Chemistry, 2017Resolvin D5 (RvD5) is a metabolite of docosahexanoic acid with anti-inflammatory activity that has not yet been thoroughly investigated because of its low biological availability. A synthetic route to optically active RvD5 was developed by assembling the C1-C10 aldehyde, C11-C13 phosphonium salt, and C14-C22 aldehyde building blocks.
Narihito Ogawa +4 more
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Stereocontrolled synthesis of resolvin D1
Organic & Biomolecular Chemistry, 2019Four pieces were assembled by the reactions indicated, and the dehydro precursor was semi-hydrogenated to give resolvin D1 (RvD1).
Masao Morita +2 more
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Stereocontrolled Synthesis of Resolvin D4
The Journal of Organic Chemistry, 2018The stereoselective synthesis of resolvin D4 (RvD4) was achieved using the Wittig reaction of the C1-C10 dienal with the known C11-C22 phosphonium salt. The ( S, E)-enantiomer ( S)-10, corresponding to the C1-C8 part, was synthesized in 95% ee by the asymmetric transfer hydrogenation reaction of the corresponding acetylenic ketone followed by Red-Al ...
Masao Morita, Yuichi Kobayashi
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Science Translational Medicine, 2016
Plaque progression was halted by inducing inflammation resolution in the blood vessel walls of a mouse model of atherosclerosis with the preresolving lipid mediator RvD1.
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Plaque progression was halted by inducing inflammation resolution in the blood vessel walls of a mouse model of atherosclerosis with the preresolving lipid mediator RvD1.
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The utilisation of resolvins in medicine and tissue engineering
Acta Biomaterialia, 2022Recent advances in the field of regenerative medicine and biomaterial science have highlighted the importance of controlling immune cell phenotypes at the biomaterial interface. These studies have clearly indicated that a rapid resolution of the inflammatory process, mediated by a switch in the macrophage population towards a reparative phenotype, is ...
Fanny Blaudez +3 more
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