Results 91 to 100 of about 12,303,189 (383)

A cohort study of the effectiveness of influenza vaccine in older people, performed using the United Kingdom general practice research database.

, 2004
BACKGROUND: The effectiveness of influenza vaccination against hospitalization and death can only ethically be assessed in observational studies. A concern is that individuals who are vaccinated are healthier than individuals who are not vaccinated ...
Cumberland, Phillippa, Cutts, Felicity T, Hall, Andrew J, Hodgson, Cathy R, Mangtani, Punam, Roberts, Jennifer A   +5 more
core   +1 more source

Viral pneumonia in adults and older children in sub-Saharan Africa — epidemiology, aetiology, diagnosis and management [PDF]

, 2014
Community-acquired pneumonia causes substantial morbidity and mortality in sub-Saharan Africa with an estimated 131 million new cases each year. Viruses — such as influenza virus, respiratory syncytial virus and parainfluenza virus — are now recognised ...
Ho, Antonia
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review

BMC Infectious Diseases
Background/Objective With the development of society, pulmonary fungal diseases, represented by pulmonary aspergillosis and pulmonary cryptococcosis, have become increasingly common.
Xidong Wang, Shaoqiang Li, Mangui Zhu, Ye Qiu, Yilei Hui, Yongming Li, Yangqing Zhan, Yan Wang, Feng Ye, Zhengtu Li   +9 more
doaj   +1 more source

Epidemiology of parainfluenza virus type 3 in England and Wales over a ten-year period [PDF]

, 1989
We have analysed data on respiratory syneytial (RS) and parainfiuenza type 3 (PF3) viruses reported to the Communicable Disease Surveillance Centre. London, over the period 1978–87.
Easton, A. J. (Andrew J.), Eglin, R. P.
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway

Signal Transduction and Targeted Therapy
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease.
Guichuan Huang, Xiangsheng Yang, Qingyang Yu, Qun Luo, Chunrong Ju, Bangyan Zhang, Yijing Chen, Zihan Liang, Shu Xia, Xiaohua Wang, Dong Xiang, Nanshan Zhong, Xiao Xiao Tang   +12 more
doaj   +1 more source

Seasonal patterns of oral antihistamine and intranasal corticosteroid purchases from Australian community pharmacies : a retrospective observational study [PDF]

, 2017
Acknowledgments The abstract of this paper was presented at the Respiratory Effectiveness Group 2016 Annual Summit as a poster presentation with interim findings.
Bosnic-Anticevich, Sinthia Z, Carney, A. Simon, Carter, Victoria, Christian, Louise, Durieux, Alice M. S., Harvey, Richard, Kritikos, Vicky, Price, David B., Skinner, Derek A., Smith, Pete K.   +9 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correction to: Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study

Trials, 2020
After publication of our article [1] the authors have notified us of two typos in the Trial status.
Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu, Jian Wang   +8 more
doaj   +1 more source