Results 71 to 80 of about 2,315,184 (310)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

High-throughput next-generation sequencing for identifying pathogens during early-stage post-lung transplantation

BMC Pulmonary Medicine, 2021
Background High-throughput next-generation sequencing (HT-NGS) has the potential to detect a large variety of pathogens; however, the application of HT-NGS in lung transplant (LTx) recipients remains limited.
Qiao-yan Lian, Ao Chen, Jian-heng Zhang, Wei-jie Guan, Xin Xu, Bing Wei, Dan-xia Huang, Jian-xing He, Chun-rong Ju   +8 more
doaj   +1 more source

COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. [PDF]

, 2020
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19), an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Patients with COVID-19 can progress from asymptomatic or
Greenland, John R, London, Martin J, Michelow, Marilyn D, Wang, Linlin   +3 more
core  

Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease. [PDF]

, 2017
Extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle ...
Abdo, Zaid, Aly, Sharif S, Belk, Keith, Blanchard, Patricia C, Davis, Jessica H, Lehenbauer, Terry W, Miller, Michael R, Morley, Paul, Noyes, Noelle, O'Rourke, Sean M, Owen, Joseph R, Prince, Daniel J, Van Eenennaam, Alison L, Young, Amy E   +13 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review

BMC Infectious Diseases
Background/Objective With the development of society, pulmonary fungal diseases, represented by pulmonary aspergillosis and pulmonary cryptococcosis, have become increasingly common.
Xidong Wang, Shaoqiang Li, Mangui Zhu, Ye Qiu, Yilei Hui, Yongming Li, Yangqing Zhan, Yan Wang, Feng Ye, Zhengtu Li   +9 more
doaj   +1 more source

Epidemiology of parainfluenza virus type 3 in England and Wales over a ten-year period [PDF]

, 1989
We have analysed data on respiratory syneytial (RS) and parainfiuenza type 3 (PF3) viruses reported to the Communicable Disease Surveillance Centre. London, over the period 1978–87.
Easton, A. J. (Andrew J.), Eglin, R. P.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway

Signal Transduction and Targeted Therapy
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease.
Guichuan Huang, Xiangsheng Yang, Qingyang Yu, Qun Luo, Chunrong Ju, Bangyan Zhang, Yijing Chen, Zihan Liang, Shu Xia, Xiaohua Wang, Dong Xiang, Nanshan Zhong, Xiao Xiao Tang   +12 more
doaj   +1 more source

Mortality among Lifelong Nonsmokers Exposed to Secondhand Smoke at Home: Cohort Data and Sensitivity Analyses [PDF]

, 2006
Evidence is growing that secondhand smoke can cause death from several diseases. The association between household exposure to secondhand smoke and disease-specific mortality was examined in two New Zealand cohorts of lifelong nonsmokers (‘‘never smokers’
Blakely, Tony, Hill, Sarah, Kawachi, Ichiro, Woodward, Alistair   +3 more
core   +2 more sources