Results 81 to 90 of about 2,315,184 (310)

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts

Stem Cell Research & Therapy
Background Human bronchial epithelial cell-derived extracellular vesicles have demonstrated the ability to attenuate fibroblasts activation. However, the specific key effector cell populations mediating this inhibitory effect remain unidentified.
Lisi Luo, Huijie Yang, Junfeng Huang, Difei Chen, Yushan He, Jinsheng Lin, Haikang Zeng, Chu Hua, Zikai Lin, Minting Wu, Yuqin Ma, Qilin Deng, Ming Liu, Shiyue Li   +13 more
doaj   +1 more source

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. [PDF]

, 2017
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens.
Behura, Susanta K, Gershwin, Laurel J, Grupioni, Natalia V, Kim, JaeWoo, Neibergs, Holly L, Regitano, Luciana CA, Schnabel, Robert D, Seabury, Christopher M, Taylor, Jeremy F, Tizioto, Polyana C, Toaff-Rosenstein, Rachel, Van Eenennaam, Alison L   +11 more
core   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

One-step diagnosis of infection and lung cancer using metagenomic sequencing

Respiratory Research
Background Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious
Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye   +9 more
doaj   +1 more source

Statistical Methodological Issues in Studies of Air Pollution and Respiratory Disease. [PDF]

Epidemiological studies have consistently shown short term associations between levels of air pollution and respiratory disease in countries of diverse populations, geographical locations and varying levels of air pollution and climate.
Erbas, B., Hyndman, R.J.
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Prognostic Predictors of Bronchial Thermoplasty for Symptom Control in Severe Asthma

Journal of Asthma and Allergy
Jia Pan,1,2,* Ming-Lu Zhong,3,* Xiao-Yi Pan,1,2,* Sha-Sha He,1 Ying-Bo Wu,1 Shi-Yue Li,1 Zhu-Quan Su1 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of ...
Pan J, Zhong ML, Pan XY, He SS, Wu YB, Li SY, Su ZQ   +6 more
doaj  

Rituximab induced sympathetic crashing acute pulmonary oedema in a patient with interstitial lung disease: a rare and lifethreatening complication

Asian Journal of Internal Medicine
Rituximab is a monoclonal antibody widely used to treat autoimmune diseases and haematologic malignancies. Although generally well tolerated, it can cause severe infusion-related reactions, including pulmonary complications.
K. Maduranga, S. N. H. Nimesha, A. Srirangan, E. perara   +3 more
doaj   +1 more source