Results 71 to 80 of about 11,837,947 (410)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The air we breathe [PDF]

, 1993
Air pollution has been associated with respiratory ill health for centuries and in recent years much research effort has gone into quantifying the risks and elucidating the mechanisms. Respiratory disease, mostly of the airways is second only by a narrow
Ebejer, Martin J.
core  

Severe acute respiratory syndrome (SARS): breathtaking progress [PDF]

, 2003
Reports of a new severe respiratory disease, now defined as severe acute respiratory syndrome (SARS), began to emerge from Guangdong, in southern China, in late 2002.
Bhagani, S, Gillespie, SH, Hawkey, PM
core   +2 more sources

Optimal Positive End Expiratory Pressure Levels in Ventilated Patients Without Acute Respiratory Distress Syndrome: A Bayesian Network Meta-Analysis and Systematic Review of Randomized Controlled Trials

Frontiers in Medicine, 2021
Background: To find the optimal positive end expiratory pressure (PEEP) in mechanical ventilated patients without Acute Respiratory Distress Syndrome (ARDS), we conducted a Bayesian network meta-analysis and systematic review of randomized controlled ...
Jing Zhou, Zhimin Lin, Xiumei Deng, Baiyun Liu, Yu Zhang, Yongxin Zheng, Haichong Zheng, Yingzhi Wang, Yan Lai, Weixiang Huang, Xiaoqing Liu, Weiqun He, Yuanda Xu, Yimin Li, Yongbo Huang, Ling Sang, Ling Sang   +16 more
doaj   +1 more source

The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status

Military Medical Research, 2020
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention.
Yanrong Guo, Qing Cao, Z. Hong, Yuan-Yang Tan, Shou-Deng Chen, Hongjun Jin, K. Tan, D. Wang, Yan Yan   +8 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy

Developmental Medicine & Child Neurology, 2019
To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population.
J. Ryan, M. Peterson, N. Ryan, Kimberley J Smith, N. O’Connell, S. Liverani, N. Anokye, C. Victor, E. Allen   +8 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs. [PDF]

, 2020
Pulmonary hypertension (PH), defined by increased pressure within the pulmonary vasculature, is a hemodynamic and pathophysiologic state present in a wide variety of cardiovascular, respiratory, and systemic diseases.
Abbott, Jonathan, Borgarelli, Michele, Clercx, Cécile, Kellihan, Heidi B, Masseau, Isabelle, Reinero, Carol, Rozanski, Elizabeth, Scansen, Brian A, Visser, Lance C, Williams, Kurt   +9 more
core   +3 more sources