Results 81 to 90 of about 12,303,189 (383)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

"Acute Respiratory Disease" [PDF]

Medical Clinics of North America, 1947
C H, RAMMELKAMP, J H, DINGLE
  +7 more sources

Sarcoidosis Presenting as Acute Respiratory Distress Syndrome. [PDF]

, 2018
Sarcoidosis is a multisystem granulomatous disease of unknown origin. It typically involves the lungs and mediastinal lymph nodes in a chronic fashion. However, acute syndrome has been reported possibly in response to systemic release of proinflammatory ...
Chan, Vincent, Lashari, Bilal, Raza, Ahmad, Ward, William   +3 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources

Improving the quality of life of people with advanced respiratory disease and severe breathlessness

Breathe, 2019
Advanced respiratory disease imposes a greater symptom burden than many cancers but not does have comparable recognition of the need for supportive and palliative care or the infrastructure for its systematic delivery.
S. Booth, Miriam J. Johnson
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Bronchoscopy, Imaging, and Concurrent Diseases in Dogs with Bronchiectasis: (2003-2014). [PDF]

, 2015
BackgroundBronchiectasis is a permanent and debilitating sequel to chronic or severe airway injury, however, diseases associated with this condition are poorly defined.ObjectiveTo evaluate results of diagnostic tests used to document bronchiectasis and ...
Byrne, BA, Johnson, EG, Johnson, LR, Kass, PH, Vernau, W   +4 more
core   +1 more source

Sleep in chronic respiratory disease: COPD and hypoventilation disorders

European Respiratory Review, 2019
COPD and obstructive sleep apnoea (OSA) are highly prevalent and different clinical COPD phenotypes that influence the likelihood of comorbid OSA.
W. McNicholas, Daniel Hansson, S. Schiza, L. Grote   +3 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source