Results 51 to 60 of about 1,201,684 (350)

Respiratory Therapy Modalities in the Treatment of Acute Respiratory Failure [PDF]

, 1978
Rapid advances have been made in the field of respiratory therapy in the past several years, resulting in an increasing sophistication and range of application.
Mathers, James A. L., Jr.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Clinical practices, self-confidence, and perceived barriers in tracheostomy care among respiratory therapists in Saudi Arabia: a national cross-sectional study

BMC Medical Education
Background Tracheostomy care is a critical aspect of respiratory therapy, requiring specialized knowledge and adherence to standardized protocols to ensure optimal patient outcomes.
Abdulelah M. Aldhahir, Ahmed H. Alasimi, Yunus A. Jothmi, Muhannad N. Khowaji, Abdullah A. Najaei, Jehad M. Rayyani, Ammar N. Alwadani, Abdullah A. Alqarni, Jaber S. Alqahtani, Rayan A. Siraj, Munyra Alhotye, Mohammed A. Reyany, Mohamed H. Hakamy, Mohammad A. Shawany, Ali Hakamy   +14 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The impact of aerosolized mucolytic agents on the airflow resistance of bacterial filters used in mechanical ventilation

Journal of the Formosan Medical Association, 2015
In order to reduce the contamination in the ventilator, bacterial filters were placed on the expiratory limb of a ventilator circuit. Aerosolized mucolytic agents may increase the resistance of the ventilator.
Han-Chung Hu, Hsin-Chun Liu, Yen-Huey Chen, Chung-Chi Huang, Gwo-Hwa Wan, Lan-Ti Chou, Meng-Jer Hsieh, Ning-Hung Chen, Cheng-Ta Yang, Kuo-Chin Kao   +9 more
doaj   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Virtual pulmonary rehabilitation approaches in patients with post COVID syndrome: a pilot study

BMC Pulmonary Medicine
Background The characteristics of optimal virtual pulmonary rehabilitation (PR) for individuals with post-COVID syndrome (PCS) have not been identified.
Antonio Sarmento, Rachel Adodo, Greg Hodges, Sandra C. Webber, Diana C. Sanchez-Ramirez   +4 more
doaj   +1 more source

Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study

Pharmaceutics, 2020
We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation.
Tien-Pei Fang, Yu-Ju Chen, Tsung-Ming Yang, Szu-Hu Wang, Ming-Szu Hung, Shu-Hua Chiu, Hsin-Hsien Li, James B. Fink, Hui-Ling Lin   +8 more
doaj   +1 more source

Diagnosis and management of pneumonia in the emergency department. [PDF]

, 2008
Pneumonia is a condition that is often treated by emergency physicians. This article reviews the diagnosis and management of pneumonia in the emergency department and highlights dilemmas in diagnostic testing, use of blood and sputum cultures, hospital ...
Abrahamian, Fredrick M, Moran, Gregory J, Talan, David A   +2 more
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