Results 11 to 20 of about 11,514 (172)

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

Nature Communications
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion glycoprotein (F).
Nicole V. Johnson, Revina C. van Scherpenzeel, Mark J. G. Bakkers, Ajit R. Ramamohan, Daan van Overveld, Lam Le, Johannes P. M. Langedijk, Joost A. Kolkman, Jason S. McLellan   +8 more
doaj   +4 more sources

Virological Surveillance and Molecular Characterization of Human Parainfluenzavirus Infection in Children with Acute Respiratory Illness: Germany, 2015–2019 [PDF]

Microorganisms, 2021
Human parainfluenza viruses (HPIVs) are important causes of respiratory illness, especially in young children. However, surveillance for HPIV is rarely performed continuously, and national-level epidemiologic and genetic data are scarce.
Djin-Ye Oh, Barbara Biere, Markus Grenz, Thorsten Wolff, Brunhilde Schweiger, Ralf Dürrwald, Janine Reiche   +6 more
doaj   +3 more sources

Identification and Genetic Characterization of a Novel Respirovirus in Alpine Chamois (Rupicapra rupicapra rupicapra) [PDF]

Animals, 2020
The Respirovirus genus, family Paramamixoviridae, includes respiratory viral pathogens. Here we report the identification and genetic characterization of a respirovirus in an Alpine chamois showing interstitial pneumonia associated with catarrhal ...
Camilla Luzzago, Erika Ebranati, Antonio Lavazza, Martina Besozzi, Gianguglielmo Zehender, Paolo Lanfranchi, Stefania Lauzi   +6 more
doaj   +3 more sources

Porcine Respirovirus 1 Suppresses Host Type I Interferon Production and the JAK-STAT Signaling Pathway

Viruses, 2023
Porcine respirovirus 1 (PRV1), first reported in Hong Kong, is currently widely spread in several countries. Our knowledge of the clinical significance and the pathogenicity of this virus is still limited.
Yanhua Li, Chenxi Li
doaj   +3 more sources

Divergent Viruses Discovered in Swine Alter the Understanding of Evolutionary History and Genetic Diversity of the Respirovirus Genus and Related Porcine Parainfluenza Viruses

Microbiology Spectrum, 2022
Paramyxoviridae is a rapidly growing family of viruses, whose potential for cross-species transmission makes it difficult to predict the harm of newly emerging viruses to humans and animals. To better understand their diversity, evolutionary history, and
Jin Zhao, Jiumeng Sun, Xinxin Li, Gang Xing, Yifang Zhang, Alexander Lai, Guy Baele, Xiang Ji, Shuo Su   +8 more
doaj   +4 more sources

Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor. [PDF]

PLoS Pathogens, 2009
A number of paramyxoviruses are responsible for acute respiratory infections in children, elderly and immuno-compromised individuals, resulting in airway inflammation and exacerbation of chronic diseases like asthma.
Grégory Caignard, Anastassia V Komarova, Mehdi Bouraï, Thomas Mourez, Yves Jacob, Louis M Jones, Flore Rozenberg, Astrid Vabret, François Freymuth, Frédéric Tangy, Pierre-Olivier Vidalain   +10 more
doaj   +6 more sources

Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling. [PDF]

FEBS Letters, 2019
Respirovirus C protein blocks the type I interferon (IFN)-stimulated activation of the JAK-STAT pathway. It has been reported that C protein inhibits IFN-α-stimulated tyrosine phosphorylation of STATs, but the underlying mechanism is poorly understood ...
GOTOH Bin, ITOH Masae, KITAGAWA Yoshinori, KOHNO Miki, SAKAI Madoka, YAMAGUCHI Mayu, 北川 善紀, 後藤 敏   +7 more
core   +5 more sources

Genetic diversity and evolutionary analysis of human respirovirus type 3 strains isolated in Kenya using complete hemagglutinin-neuraminidase (HN) gene.

PLoS ONE, 2020
Human respirovirus type 3 (HRV3) is a leading etiology of lower respiratory tract infections in young children and ranks only second to the human respiratory syncytial virus (HRSV).
Juliet Elusah, Wallace Dimbuson Bulimo, Silvanos Mukunzi Opanda, Samwel Lifumo Symekher, Fred Wamunyokoli   +4 more
doaj   +4 more sources

The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection [PDF]

Virology Journal
Background Mycoplasma pneumoniae (MP) is a common pathogen for respiratory infections in children. Previous studies have reported respiratory tract microbial disturbances associated with MP infection (MPI); however, since the COVID-19 pandemic ...
Dianqi Zhang, Yang Cao, Biao Dai, Teng Zhang, Xing Jin, Qingyue Lan, Chaoying Qian, Yumin He, Yi Jiang   +8 more
doaj   +2 more sources

Intranasal vaccine against COVID-19 based on a recombinant variant of the Sendai virus (Paramyxoviridae: Respirovirus) strain Moscow

Вопросы вирусологии, 2023
Introduction. Intranasal vaccination using live vector vaccines based on non-pathogenic or slightly pathogenic viruses is the one of the most convenient, safe and effective ways to prevent respiratory infections, including COVID-19.
Gleb A. Kudrov, Sergei S. Zainutdinov, Antonina A. Grazhdantseva, Andrey V. Shipovalov, Galina F. Sivolobova, Anastasiya V. Semenova, Iuliia A. Merkuleva, Dmitry N. Shcherbakov, Oleg S. Taranov, Anna V. Zaykovskaya, Irina S. Shulgina, Oleg V. Pyankov, Galina V. Kochneva   +12 more
doaj   +2 more sources