Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks of two distinct human respiratory viruses, human metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and human respirovirus 3 (
Jacob D. Negrey +17 more
doaj +1 more source
Human IFIT1 inhibits mRNA translation of rubulaviruses but not other members of the Paramyxoviridae family [PDF]
This work was supported by The Welcome Trust (101788/Z/13/Z, 101792/Z/13/Z) and Medical research council grant (G1100110/1, MR/K024213/1).We have previously shown that IFIT1 is primarily responsible for the antiviral action of interferon (IFN) alpha/beta
Andrejeva, J. +7 more
core +4 more sources
An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]
: Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus +57 more
core +4 more sources
The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy [PDF]
The recent focus on the cystic fibrosis (CF) complex microbiome has led to the recognition that the microbes can interact between them and with the host immune system, affecting the disease progression and treatment routes.
A Bragonzi +159 more
core +1 more source
Complete Genome Characterization of Eight Human Parainfluenza Viruses from the Netherlands. [PDF]
We report the complete genome sequences of eight human parainfluenza viruses (HPIV) belonging to Human respirovirus 1 (HPIV-1), Human respirovirus 3 (HPIV-3), Human rubulavirus 2 (HPIV-2), and Human rubulavirus 4 (HPIV-4).
Arron, Georgina +6 more
core +2 more sources
Comprehensive Detection of Candidate Pathogens in the Lower Respiratory Tract of Pediatric Patients With Unexpected Cardiopulmonary Deterioration Using Next-Generation Sequencing [PDF]
Objectives: Next-generation sequencing has been applied to the investigation of microorganisms in several clinical settings. We investigated the infectious etiologies in respiratory specimens from pediatric patients with unexpected cardiopulmonary ...
103497 +21 more
core +1 more source
Thoracic Ultrasonography Findings and Their Association With Respiratory Pathogens in 221 Young Beef Cattle at Fattening Farms: A Cross-Sectional Study. [PDF]
ABSTRACT Background Thoracic ultrasonography (TUS) could improve antibiotic treatment selection in cattle with respiratory diseases. Hypothesis/Objectives Evaluate the association between respiratory pathogens and consolidations on TUS in feedlot cattle, at both individual and group levels. Animals A total of 221 bulls, aged 8.8 months and weighing 322.
Rouault M +3 more
europepmc +2 more sources
The cellular tail-interacting 47-kDa protein (TIP47) acts positively on HIV-1 and vaccinia virus production. We show here that TIP47, in contrast, acts as a restriction factor for Sendai virus production. This conclusion is supported by the occurrence of increased or decreased virus production upon its suppression or overexpression, respectively. Pulse-
Bampi, Carole +4 more
openaire +7 more sources
Prevalence Estimation and Genetic Characterization of Porcine Parainfluenza Virus 1 (PPIV-1) in Hungary and the First Report of the Virus in Slovakia. [PDF]
In the last few decades, many new paramyxoviruses have been discovered, causing diverse, mostly respiratory diseases in animals and humans. The porcine parainfluenza virus 1 (PPIV‐1, species Porcine respirovirus 1), which has been reported in many countries worldwide, was found in both healthy and clinically ill pigs showing respiratory signs. Here, we
Igriczi B +5 more
europepmc +2 more sources
Orthoparamyxovirinae C Proteins Have a Common Origin and a Common Structural Organization [PDF]
The protein C is a small viral protein encoded in an overlapping frame of the P gene in the subfamily Orthoparamyxovirinae. This protein, expressed by alternative translation initiation, is a virulence factor that regulates viral transcription ...
Baudin, Florence +10 more
core +1 more source

