Structural basis of phosphorylation-induced activation of the response regulator VbrR [PDF]
Acta Biochimica et Biophysica Sinica, 2023 Two-component systems typically consist of a paired histidine kinase and response regulator and couple environmental changes to adaptive responses. The response regulator VbrR from Vibrio parahaemolyticus, a member of the OmpR/PhoB ...
Hong Sen +5 more
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Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator [PDF]
mBio, 2023 Antibiotic tolerance within a biofilm community presents a serious public health challenge. Here, we report the identification of a 2-aminoimidazole derivative that inhibits biofilm formation by two pathogenic Gram-positive bacteria, Streptococcus mutans
Chang Liu +10 more
doaj +2 more sources
A single-domain response regulator activates exopolysaccharide biosynthesis by interaction with the initiating phosphoglycosyl transferase [PDF]
mBioExported polysaccharides play crucial functions in bacteria. Polysaccharide biosynthesis in the ubiquitous Wzx/Wzy- and ABC-transporter-dependent pathways starts with the transfer of a sugar-1-phosphate from a nucleotide-sugar donor to undecaprenyl ...
Johannes Schwabe +7 more
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PhcX Is a LqsR-family response regulator that contributes to Ralstonia solanacearum virulence and regulates multiple virulence factors [PDF]
mBio, 2023 As one of the most notorious and successful phytopathogenic bacteria, Ralstonia solanacearum controls the transition between long-term survival and pathogenic modes through an intricate regulatory network, the understanding of which remains incomplete ...
Qingmei Liu +11 more
doaj +2 more sources
Mechanistic and biophysical characterization of polymyxin resistance response regulator PmrA in Acinetobacter baumannii [PDF]
Frontiers in MicrobiologyIntroductionAcinetobacter baumannii PmrAB is a crucial two-component regulatory system (TCS) that plays a vital role in conferring resistance to polymyxin.
Zhenlin Ouyang +10 more
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The response regulator CrsR positively regulates ansamitocin P-3 biosynthesis in Actinosynnema pretiosum [PDF]
Frontiers in MicrobiologyAnsamitocin P-3 (AP-3), a maytansinoid antibiotic produced by Actinosynnema pretiosum, exhibits potent anticancer activity. However, its biosynthetic regulation in A. pretiosum remains largely unknown.
Peipei Zhang +11 more
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Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of
mSystems, 2020 Bordetella pertussis regulates the production of its virulence factors by the two-component system BvgAS. In the virulence phase, BvgS phosphorylates BvgA, which then activates the transcription of virulence-activated genes (vags).
Loïc Coutte +7 more
doaj +3 more sources
Plants, 2020 Two-component systems (TCSs) have been identified as participants in mediating plant response to water deficit. Nevertheless, insights of their contribution to plant drought responses and associated regulatory mechanisms remain limited. Herein, a soybean
Duong Hoang Trong Nghia +10 more
doaj +1 more source
Global View on the Cytokinin Regulatory System in Potato
Frontiers in Plant Science, 2020 Cytokinins (CKs) were earlier shown to promote potato tuberization. Our study aimed to identify and characterize CK-related genes which constitute CK regulatory system in the core potato (Solanum tuberosum) genome.
Sergey N. Lomin +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated
Scott N. Dean +3 more
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