Results 201 to 210 of about 761,074 (261)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Acclimation to high daily thermal amplitude converts a defense response regulator into susceptibility factor

Didelon M, Sucher J, Carvalho-Silva P, Zaffuto M, Barbacci A, Raffaele S.   +5 more
europepmc   +1 more source

The Promising B-Type Response Regulator hst1 Gene Provides Multiple High Temperature and Drought Stress Tolerance in Rice. [PDF]

Int J Mol Sci
Lopes Hornai EM, Aycan M, Mitsui T.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in Listeria monocytogenes under Benzalkonium Chloride Stress. [PDF]

Microorganisms
Yu T, Jiang X, Xu X, Xu P, Qiu S, Yin J, Hamilton DP, Jiang X.   +7 more
europepmc   +1 more source

Combatting Antibiotic-Resistant Staphylococcus aureus: Discovery of TST1N-224, a Potent Inhibitor Targeting Response Regulator VraRC, through Pharmacophore-Based Screening and Molecular Characterizations. [PDF]

J Chem Inf Model
Hsu YC, Liu CH, Wu YC, Lai SJ, Lin CJ, Tseng TS.   +5 more
europepmc   +1 more source

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Regulation and responsible innovation

The Journal of Law, Economics, and Organization
Abstract Should product harms be investigated by firms via “Responsible Innovation” (RI) or by regulators? Firms can investigate potential harms early on, but only by diverting resources from innovation. Regulators, by contrast, often investigate harms after products are on the market.
Nicolas Figueroa, Carla Guadalupi, Jorge Lemus   +2 more
openaire   +1 more source

Responsive Regulation

1992
Abstract Drawing extensively on empirical studies from the US, UK, Australia, and New Zealand, John Braithwaite and Ian Ayres offer an well-argued addition to the comparative literature on government regulation. In an effort to transcend the ongoing debate between those who favour strong state regulation and those who call for ...
Ian Ayres, John Braithwaite
openaire   +1 more source

Regulated Regulation in Immune Responses

Science, 2005
The activity of regulatory T cells (T-reg) is responsible for controlling aberrant immune responses and autoimmunity, but these cells represent a potential barrier to certain types of therapeutic manipulation, such as in cancer immunotherapy. Peng et al .
openaire   +2 more sources