Results 101 to 110 of about 4,958,218 (328)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Microwave Response and Spin Waves in Superconducting Ferromagnets

, 2006
Excitation of spin waves is considered in a superconducting ferromagnetic slab with the equilibrium magnetization both perpendicular and parallel to the surface. The surface impedance is calculated and its behavior near propagation thresholds is analyzed.
A. I. Akhiezer, L. D. Landau, L. D. Landau, U. Krey, V. Braude   +4 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strength and durability of concrete with bentonite clay and quarry dust

Frontiers in Materials
The research object is concrete with supplementary cementitious materials (SCMs) such as bentonite clay and quarry dust. The impact of incorporating these SCMs on fresh concrete properties, compressive, flexural, and split tensile strengths, and acid ...
Muhammad Umar, Hui Qian, M. Nasir Ayaz Khan, Muhammad Shahid Siddique, Hamad Almujibah, Ali. E. A. Elshekh, Maaz Osman Bashir, Nikolai Ivanovich Vatin   +7 more
doaj   +1 more source

Optimisation of the Extrusion Process through a Response Surface Methodology for Improvement of the Physical Properties and Nutritional Components of Whole Black-Grained Wheat Flour [PDF]

, 2021
Yuxiu Liu, Miao Liu, Shuhua Huang, Zhengmao Zhang   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Optimization of extraction process of polysaccharides from mulberry leaves and determination of the antioxidant activity in vitro

Shipin yu jixie
ObjectiveThis study aimed to optimize the extraction process of polysaccharides from mulberry leaves using deep eutectic slovents (DES) and assess their antioxidant properties.MethodsAutumn mulberry leaf powder was used as the raw material, and ...
WU Jun, YANG Biwen, ZHAO Pei, MA Jingqiu, WANG Xiaojing, HUANG Yue   +5 more
doaj   +1 more source

Acoustic surface plasmons in the noble metals Cu, Ag, and Au

, 2005
We have performed self-consistent calculations of the dynamical response of the (111) surface of the noble metals Cu, Ag, and Au. Our results indicate that the partially occupied surface-state band in these materials yields the existence of acoustic ...
A. L. Fetter, A. Liebsch, A. V. Chaplik, A. V. Chaplik, E. V. Chulkov, J. M. Pitarke, P. M. Echenique, S. Hüfner, V. M. Silkin   +8 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Randomized response surface pathway design with odd response outcomes in a Latin Square designed study

Open Access Journal of Clinical Trials, 2017
Trond Holand,1 Kristian Ellingsen,2 Sagita Dewi,1,3 Stig Larsen1 1Centre for Epidemiology and Biostatistics, Department of Production Animal Clinical Sciences, Faculty of Veterinary Science, Norwegian University of Life Science, 2Norwegian Veterinary ...
Holand T, Ellingsen K, Dewi S, Larsen S
doaj