Results 61 to 70 of about 1,313,206 (306)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optimization of Factors Affecting Beauveria bassiana Fungus Ability in Control of Greater Wax Moth (Galleria mellonella L.) by Response Surface Method

Majallah-i ḥifāẓat-i giyāhān, 2017
Introduction: Stored product pests are a major problem in the storage of agricultural products that cause damage from harvest until consumption. Greater Wax Moth (Galleria mellonella L.) is one of the most important pests of stored products and beehives.
Ali Heidari, shahrokh gharanjik, Ali Derakhshan Shadmehri, Alireza Shabaninejad   +3 more
doaj   +1 more source

A rainfall loading response recorded at 300 meters depth: implications for geological weighing lysimeters

, 2006
Static pore water pressures in confined aquifers vary in response to ground surface loading changes, including precipitation and evaporation. Under certain hydrogeological conditions such aquifers can function as giant natural weighing lysimeters ...
Sophocleous, Marios, Healey, John, Bardsley, W. Earl   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimization Parameters for PLA Through Additive Manufacturing: Taking Mixed Shapes as an Example

Applied Sciences
In recent years, additive manufacturing has been widely used in industrial, medical, and educational fields. Material extrusion is used in most industries to increase development efficiency and reduce costs.
Dyi-Cheng Chen, Yu-Ting Chen
doaj   +1 more source

Optimization of Pigment Extraction from Red Beet [PDF]

مجله پژوهش‌های علوم و صنایع غذایی ایران
Introduction The first quality attribute about food evaluated by consumer is visual characteristics. The apparent attributes of a product include its shape, color, packaging, size, and uniformity.
Mahshad Lavarsetagh, Nafiseh Zamindar, Yasaman Esmaeili   +2 more
doaj   +1 more source

Numerical solution of the eXtended Pom-Pom model for viscoelastic free surface flows

, 2011
In this paper we present a finite difference method for solving two-dimensional viscoelastic unsteady free surface flows governed by the single equation version of the eXtended Pom-Pom (XPP) model. The momentum equations are solved by a projection method
Tome, Murilo F., C.M. Oishi, M.F. Tomé, OISHI, C. M., Oishi, C.M., J.A. Cuminato, F.P. Martins, Cuminato, J.A., Oishi, C. M. [UNESP], Cuminato, Jose, S. McKee, Tomé, M.F., Cuminato, J. A., Tome, M. F., Martins, F.P., Mckee, Sean, McKee, S., Martins, F. P. [UNESP], MARTINS, F. P.   +18 more
core   +1 more source