Results 11 to 20 of about 1,590,717 (301)

Response surface methodology revisited. [PDF]

Proceedings of the Winter Simulation Conference, 2003
Response surface methodology (RSM) searches for the input combination that optimizes the simulation output. RSM treats the simulation model as a black box. Moreover, this paper assumes that simulation requires much computer time. In the first stages of its search, RSM locally fits first-order polynomials.
Angun, M.E., Gürkan, G., Hertog, D. den, Kleijnen, J.P.C.   +3 more
core   +7 more sources

Response Surface Methodology [PDF]

SSRN Electronic Journal, 2014
This chapter first summarizes Response Surface Methodology (RSM), which started with Box and Wilson’s 1951 article on RSM for real, non-simulated systems. RSM is a stepwise heuristic that uses first-order polynomials to approximate the response surface locally.
openaire   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Maximization of fructose esters synthesis by response surface methodology [PDF]

, 2011
Enzymatic synthesis of fructose fatty acide sterwasper formed inorganic solventmedia, using apurified lipase from Candida antartica B immobilizedinacrylicresin.
Neta, Nair do Amaral Sampaio, Peres, A. M., Rodrigues, L. R., Teixeira, J. A.   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A study into compression ring dynamics using response surface methodology [PDF]

, 2015
For decades the operational dynamics of the compression ring during operation, have been subject to debate. A complex computer simulation, using Design Of Experiments (DOE) methodology, was developed to study the effect of the compression ring rotation ...
Dickinson, Matthew
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Optimization of Guide Vane Centrifugal Pumps Based on Response Surface Methodology and Study of Internal Flow Characteristics [PDF]

, 2023
Weidong Cao, He Wang, Xinyu Yang, Xinyi Leng   +3 more
openalex   +1 more source