Results 71 to 80 of about 544,708 (311)

Optimization of Yeast Protein Extraction through a Combined Enzymatic and High-Pressure Homogenization Method

Proceedings, 2020
Yeasts have a very high content of protein; therefore, they could be used as an easy source of protein. [...]
Otilia-Gabriela Bărbieru, Naomi Tritean, Bogdan Trică, Diana Constantinescu-Aruxandei, Florin Oancea   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Optimization of Pectinase Production from Bacillus velezensis Isolated from Agro-waste using Response Surface Methodology

Journal of Pure and Applied Microbiology
Pectinases are important enzymes with significant applications in the industrial processing of juice clarification, oil and tea extraction, and paper manufacturing.
Lakshmi Suresh Kottilingal, Sivagurunathan Paramasivam, Sowndarya Sivaprakasam, Chakrappully Radhakrishnan Meera, Uma Chinnaiyan   +4 more
doaj   +1 more source

Mitigation of Cr (VI) from aqueous solution using jute charcoal iron composite (JC-FeCs): Response surface methodology (RSM) [PDF]

, 2022
Binu Kumari, Rajani Kant Tiwary, Mahendra Yadav   +2 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Polymer-Based Nano-Adsorbent for the Removal of Lead Ions: Kinetics Studies and Optimization by Response Surface Methodology [PDF]

, 2022
Abdullahi Haruna Birniwa, Sana Kehili, Mujahid Ali, Haruna Musa, Umar Ali, Shamsul Rahman Mohamed Kutty, Ahmad Hussaini Jagaba, Shehu Sa’ad Abdullahi, Sayed M. Eldin, Habibun Nabi Muhammad Ekramul Mahmud   +9 more
openalex   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Optimization of chlorophyll extraction from mulberry leaves using response surface methodology

浙江大学学报. 农业与生命科学版, 2012
Chlorophyll plays an important role in our everyday life. It is used not only as an annexing agent in medicinal and calleidic products but also as an unartificial food coloring agent.
CHEN Shao-yuan, LÜ Zhen-er, DONG Feng-li, MAO Bi-zeng   +3 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source