Results 71 to 80 of about 1,343,626 (305)

Organizing as negotiation: the construction of a pathway in Norwegian mental health services

open access: yesInternational Journal of Mental Health Systems, 2021
Background In 2015, a decision was made to implement clinical pathways in Norwegian mental health services. The idea was to construct pathways similar to those used in cancer treatment.
Tine Nesboe Toerseth
doaj   +1 more source

Responsible Data Governance of Neuroscience Big Data [PDF]

open access: yes, 2019
Open access article.Current discussions of the ethical aspects of big data are shaped by concerns regarding the social consequences of both the widespread adoption of machine learning and the ways in which biases in data can be replicated and perpetuated.
Fothergill, B. Tyr   +3 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Gender-Responsive Research and Innovation: Issues and Initiatives

open access: yesSustainability
The demands and preferences of men are often prioritized in societal challenges, despite women comprising half of the world’s population. Gender-Responsive Research and Innovation (GRRI) offers an approach to address this bias, promoting comprehensive and equitable solutions to better-understood real-world problems.
Sanaz Nikghadam-Hojjati   +13 more
openaire   +3 more sources

Addressing responsible research and innovation to industry [PDF]

open access: yesACM SIGCAS Computers and Society, 2016
Responsible research and innovation (RRI) is taking a role to assist all types of stakeholders including industry to move research and innovation initiatives to responsible manner for tackling grand challenges. The literature on RRI focuses little on how industry can implement RRI principles.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Toward institutionalization of responsible research and innovation: insights from case studies of technological centers in Spain

open access: yesJournal of Responsible Innovation
The frameworks governing Responsible Research and Innovation (RRI) are heterogeneous and constantly evolving and adapting. We build upon this adaptability to explore the potential development of RRI in Research and Technology Organizations.
Hannia Gonzalez-Urango   +3 more
doaj   +1 more source

Reflections on the practice of Responsible (Research and) Innovation in synthetic biology

open access: yesNew Genetics and Society, 2020
This paper is a critical reflection on the concepts of Responsible Innovation (RI) and Responsible Research and Innovation (RRI). We offer an account of the emergence of these related but different accounts of responsible innovation that have recently ...
Ken Taylor, Simon Woods
doaj   +1 more source

Responsible, Inclusive Innovation and the Nano-divide [PDF]

open access: yes, 2016
Policy makers from around the world are trying to emulate successful innovation systems in order to support economic growth. At the same time, innovation governance systems are being put in place to ensure a better integration of stakeholder views into ...
Dalton-Brown, Sally   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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