Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Advances in Diversity, Evolutionary Dynamics and Biotechnological Potential of Restriction-Modification Systems. [PDF]
MicroorganismsChen C, Zhang Y, Wu H, Qiao J, Caiyin Q.
europepmc +1 more source
Effects of Population Dynamics on Establishment of a Restriction-Modification System in a Bacterial Host [PDF]
, 2019 Stefan Graovac +4 more
openalex +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria. [PDF]
Microbiol Spectr, 2023 Xu C +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Characterization of the Staphylococcus xylosus methylome reveals a new variant of type I restriction modification system in staphylococci. [PDF]
Front Microbiol, 2023 Schiffer CJ +4 more
europepmc +1 more source
Site-specific methylation: effect on DNA modification methyltransferases and restriction endonucleases [PDF]
, 1991 Michael Nelson, Michael McClelland
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Various plasmid strategies limit the effect of bacterial restriction-modification systems against conjugation. [PDF]
Nucleic Acids ResDimitriu T, Szczelkun MD, Westra ER.
europepmc +2 more sources