Results 111 to 120 of about 18,327,370 (242)
The structural basis of differential DNA sequence recognition by restriction–modification controller proteins [PDF]
, 2012 McGeehan, John +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2017 Warangkhana Wanla,1 Wasan Katip,2,3 Sakon Supakul,2 Porntipa Apiwatnakorn,4 Sompong Khamsarn1 1Department of Pharmacy, Lamphun Hospital, Lamphun, Thailand; 2Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai ...
Katip W +4 more
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 2020 N6-Adenine DNA methyltransferases associated with some Type I and Type III restriction-modification (R-M) systems are able to undergo phase variation, randomly switching expression ON or OFF by varying the length of locus-encoded simple sequence repeats (
Yang, Long +6 more
core +1 more source
Improved genetic transformation by disarmament of type II Restriction-Modification system in Streptococcus zooepidemicus. [PDF]
3 Biotech, 2022 Gao W, Xie Y, Zuo M, Zhang G, Liu H.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On the restriction of the Fourier transform to polynomial curves [PDF]
, 2007 We prove a Fourier restriction theorem on curves parametrised by the mapping P(t) = (P1(t),..., Pn(t)), where each of the P1,..., Pn is a real-valued polynomial and t belongs to an interval on which each of the P1,..., Pn "resembles" a ...
Dendrinos, S.
core +1 more source
A mobile restriction-modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease. [PDF]
Nucleic Acids Res, 2022 Birkholz N +3 more
europepmc +1 more source