Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Type I Restriction Modification System Influences Genomic Evolution Driven by Horizontal Gene Transfer in Paenibacillus polymyxa. [PDF]
Front Microbiol, 2021 Chen Z +6 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Effect of Dietary Restriction on Muscle Performance in Drosophila [PDF]
, 2011 Dietary restriction (DR) can extend the lifespan in various organisms and is thought to present potential benefits in human. However, it is still a controversial issue now among scientists due to lack of strong supportive evidence in human.
Hsu, Pin-Chia
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Organization and sequence of the HpaII restriction-modification system and adjacent genes
, 1994 We report the organization of the HpaII restriction and modification (R-M) system from Haemophilus parainfluenzae (recognition sequence: 5'...CCGG...3'), the sequence of the gene coding for the HpaII restriction endonuclease, and the sequence of the ...
Roberts, R. J. +4 more
core +1 more source
Restriction modification systems in archaea: A panoramic outlook
HeliyonRestriction modification (RM) systems are one of the ubiquitous yet primitive defense responses employed by bacteria and archaea with the primary role of safeguarding themselves against invading bacteriophages.
Pallavi Gulati +4 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems
In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialized defense systems that are often clustered together on genomic islands.
Vizzarro, Grazia +3 more
core +1 more source
Cloning and characterization of EcoHK31I restriction and modification system from escherichia coli HK31. [PDF]
, 1995 by Lee Kai Fai, Calvin.Thesis (Ph.D.)--Chinese University of Hong Kong, 1995.Includes bibliographical references (leaves 159-167).ACKNOWLEDGMENTS --- p.iABSTRACT --- p.iiCONTENTS --- p.ivABBREVIATIONS --- p.xiChapter CHAPTER ONE --- General ...
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SMC-like Wadjet system prevents plasmid transfer into Clostridium cellulovorans
Applied Microbiology and BiotechnologyThis study demonstrates the impact of a Structure Maintenance of Chromosome (SMC)-like Wadjet system on the horizontal gene transfer of plasmids by conjugation to a recipient that naturally containing such a system for the first time.
Aline I. Schöllkopf +2 more
doaj +1 more source