Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of
mBio, 2020 The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake ...
Claire Durmort +11 more
doaj +8 more sources
Characterization of the Type I Restriction Modification System Broadly Conserved among Group A Streptococci [PDF]
mSphere, 2021 Although prokaryotic DNA methylation investigations have long focused on immunity against exogenous DNA, it has been recently recognized that DNA methylation impacts gene expression and phase variation in Streptococcus pneumoniae and Streptococcus suis ...
Sruti DebRoy +8 more
doaj +3 more sources
Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis. [PDF]
Nucleic Acids Res, 2020 The genomes of gut Bacteroidales contain numerous invertible regions, many of which contain promoters that dictate phase-variable synthesis of surface molecules such as polysaccharides, fimbriae, and outer surface proteins.
Ben-Assa N +13 more
europepmc +4 more sources
A mobile restriction modification system consisting of methylases on the IncA/C plasmid [PDF]
Mobile DNA, 2019 Background IncA/C plasmids play important roles in the development and dissemination of multidrug resistance in bacteria. These plasmids carry three methylase genes, two of which show cytosine specificity.
Ruibai Wang, Jing Lou, Jie Li
doaj +3 more sources
The Patchy Distribution of Restriction⁻Modification System Genes and the Conservation of Orphan Methyltransferases in Halobacteria. [PDF]
Genes (Basel), 2019 Restriction-modification (RM) systems in Bacteria are implicated in multiple biological roles ranging from defense against parasitic genetic elements, to selfish addiction cassettes, and barriers to gene transfer and lineage homogenization.
Fullmer MS +4 more
europepmc +4 more sources
IS-linked movement of a restriction-modification system. [PDF]
PLoS ONE, 2011 Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory ...
Noriko Takahashi +4 more
doaj +3 more sources
A functional bacteria-derived restriction modification system in the mitochondrion of a heterotrophic protist. [PDF]
PLoS Biology, 2021 The overarching trend in mitochondrial genome evolution is functional streamlining coupled with gene loss. Therefore, gene acquisition by mitochondria is considered to be exceedingly rare.
David S Milner +4 more
doaj +4 more sources
The LspC3-41I restriction-modification system is the major determinant for genetic manipulations of Lysinibacillus sphaericus C3-41. [PDF]
BMC Microbiol, 2017 Lysinibacillus sphaericus has been widely used in integrated mosquito control program and it is one of the minority bacterial species unable to metabolize carbohydrates. In consideration of the high genetic conservation at genomic level and difficulty of
Fu P, Ge Y, Wu Y, Zhao N, Yuan Z, Hu X.
europepmc +4 more sources
Improved transformation efficiency of group A Streptococcus by inactivation of a type I restriction modification system. [PDF]
PLoS One, 2021 Streptococcus pyogenes or group A Streptococcus (GAS) is a leading cause of bacterial pharyngitis, skin and soft tissue infections, life-threatening invasive infections, and the post-infectious autoimmune syndromes of acute rheumatic fever and post ...
Finn MB +4 more
europepmc +2 more sources
A Type I Restriction Modification System Influences Genomic Evolution Driven by Horizontal Gene Transfer in Paenibacillus polymyxa. [PDF]
Front Microbiol, 2021 Considered a “Generally Recognized As Safe” (GRAS) bacterium, the plant growth–promoting rhizobacterium Paenibacillus polymyxa has been widely applied in agriculture and animal husbandry.
Chen Z +6 more
europepmc +2 more sources