Results 181 to 190 of about 620,807 (343)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection. [PDF]

Sci Rep
Shin D, Kim T, Lee J, Kim HP, Kim TY, Bang D.   +5 more
europepmc   +1 more source

Rapid detection and characterization of foot-and-mouth disease virus by restriction enzyme and nucleotide sequence analysis of PCR products [PDF]

, 1995
Franziska Locher, V. V. S. Suryanarayana, Jon Duri Tratschin   +2 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

<i>Helicobacter pylori</i> base-excision restriction enzyme in stomach carcinogenesis. [PDF]

PNAS Nexus
Fukuyo M, Takahashi N, Hanada K, Ishikawa K, Venclovas Č, Yahara K, Yonezawa H, Terabayashi T, Katsura Y, Osada N, Kaneda A, Camargo MC, Rabkin CS, Uchiyama I, Osaki T, Kobayashi I.   +15 more
europepmc   +1 more source

SEVA 3.1: enabling interoperability of DNA assembly among the SEVA, BioBricks and Type IIS restriction enzyme standards. [PDF]

Microb Biotechnol, 2020
Damalas SG, Batianis C, Martin-Pascual M, de Lorenzo V, Martins Dos Santos VAP.   +4 more
europepmc   +1 more source

High Efficiency Restriction Enzyme–Free Linear Amplification-Mediated Polymerase Chain Reaction Approach for Tracking Lentiviral Integration Sites Does Not Abrogate Retrieval Bias

, 2012
Chuanfeng Wu, Alexander Jares, Thomas Winkler, Jianjun Xie, Jean‐Yves Métais, Cynthia E. Dunbar   +5 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxU. [PDF]

Philos Trans R Soc Lond B Biol Sci
Readshaw JJ, Lee YJ, Weigele P, Blower TR.   +3 more
europepmc   +1 more source

The MmeI family: type II restriction–modification enzymes that employ single-strand modification for host protection [PDF]

, 2009
Richard Morgan, Elizabeth Dwinell, Tanya K. Bhatia, Elizabeth M. Lang, Yvette A. Luyten   +4 more
openalex   +1 more source