Results 91 to 100 of about 3,130,340 (386)

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis [PDF]

, 2013
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the ...
Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, El Oualid, Farid, Elliott, Paul R., Freund, Stefan M. V., Geurink, Paul P., Hospenthal, Manuela K., Komander, David, Kulathu, Yogesh, Mevissen, Tycho E. T., Ovaa, Huib, Wauer, Tobias   +12 more
core  

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]

, 2014
TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA, Caiafa, Paola, Calabrese, Roberta, Ciccarone, Fabio, Franceschi, C, Guastafierro, Tiziana, Mariano, Germano, Reale, Anna, Valentini, Elisabetta, Zampieri, Michele   +9 more
core   +6 more sources

7-Deazaguanine modifications protect phage DNA from host restriction systems

Nature Communications, 2019
Genome modifications are central components of the continuous arms race between viruses and their hosts. The archaeosine base (G+), which was thought to be found only in archaeal tRNAs, was recently detected in genomic DNA of Enterobacteria phage 9g and ...
Geoffrey Hutinet, W. Kot, L. Cui, Roman Hillebrand, S. Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, A. B. Carstens, Chuan Fa Lui, D. Tremblay, D. Jacobs-Sera, M. Sassanfar, Yan-Jiun Lee, P. Weigele, S. Moineau, G. Hatfull, P. Dedon, L. Hansen, V. de Crécy-Lagard   +18 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

RFLP-kenzy: a new bioinformatics tool for in silico detection of key restriction enzyme in RFLP technique

Beni-Suef University Journal of Basic and Applied Sciences
Background Today, several bioinformatics tools are available for analyzing restriction fragment length data. RFLP-kenzy is a new bioinformatic tool for identifying restriction key enzyme that cut at least 1 sequence and a maximum of n-1 sequence. Results
Nora Laref, Khadidja Belkheir, Mohamed Belazreg, Abdelhadi Hireche   +3 more
doaj   +1 more source

Identification of predicted genes expressed differentially in pituitary gland tissue of young growing bulls revealed by cDNA-AFLP technique

Czech Journal of Animal Science, 2013
Differentially expressed transcript derived fragments (TDFs) of bovine pituitary gland tissue at different developmental ages of Limousine and Hereford bulls were identified by cDNA-AFLP technique.
C.S. Pareek, J. Michno, R. Smoczynski, J. Tyburski, M. Gołębiewski, K. Piechocki, M. Średzińska, M. Pierzchała, U. Czarnik, S. Ponsuksili, K. Wimmers   +10 more
doaj   +1 more source

In vitro Type II Restriction of Bacteriophage DNA With Modified Pyrimidines

Frontiers in Microbiology, 2020
To counteract host-encoded restriction systems, bacteriophages (phages) incorporate modified bases in their genomes. For example, phages carry in their genomes modified pyrimidines such as 5-hydroxymethyl-cytosine (5hmC) in T4gt deficient in α- and β ...
Kiersten Flodman, Ivan R. Corrêa, Nan Dai, Peter Weigele, Shuang-yong Xu   +4 more
doaj   +1 more source

MITOCHONDRIAL DNA POLYMORPHISMS AND FERTILITY IN BEEF CATTLE [PDF]

, 2002
Two regions of mitochondrial DNA, D-loop and ND-5 were characterized using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) involving 422 beef cattle of Hereford and composite breeds from Wokalup’s ...
., Sutarno, A.J, Lymbery, J.M, Cummins, RCA, Thompson   +3 more
core  

Machines on Genes: Enzymes that Make, Break and Move DNA and RNA [PDF]

, 2010
As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable ...
Bates, Belousoff, Ben F. Luisi, Lilley, Marshall, Olorunniji, Rice, Richard P. Bowater, Sherratt, Smith, Szczelkun, Tomlinson, W. Marshall Stark, Weinzierl   +13 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source