Results 161 to 170 of about 2,915,798 (345)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Restriction enzymes use a 24 dimensional coding space to recognize 6 base long DNA sequences. [PDF]

PLoS One, 2019
Schneider TD, Jejjala V.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pyrite cloning: a single tube and programmed reaction cloning with restriction enzymes. [PDF]

Plant Methods, 2018
Fischer MD, Mgboji E, Liu Z.
europepmc   +1 more source

The MmeI family: type II restriction–modification enzymes that employ single-strand modification for host protection [PDF]

, 2009
Richard Morgan, Elizabeth Dwinell, Tanya K. Bhatia, Elizabeth M. Lang, Yvette A. Luyten   +4 more
openalex   +1 more source

Genome modifications in plant cells by custom-made restriction enzymes.

Plant Biotechnology Journal, 2012
T. Tzfira, D. Weinthal, I. Marton, Vardit Zeevi, A. Zuker, A. Vainstein   +5 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Diffdigester.uni-jena.de: a tool for optimized selection of restriction enzymes for plasmid identification in cloning procedures. [PDF]

Nucleic Acids Res
Gühmann M, Reuter S, Mrowka R.
europepmc   +1 more source

Further Probing of Cu²⁺-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes. [PDF]

Molecules, 2019
Luige O, Murtola M, Ghidini A, Strömberg R.   +3 more
europepmc   +1 more source

High Efficiency Restriction Enzyme–Free Linear Amplification-Mediated Polymerase Chain Reaction Approach for Tracking Lentiviral Integration Sites Does Not Abrogate Retrieval Bias

, 2012
Chuanfeng Wu, Alexander Jares, Thomas Winkler, Jianjun Xie, Jean‐Yves Métais, Cynthia E. Dunbar   +5 more
openalex   +2 more sources