Results 191 to 200 of about 1,662,191 (275)

CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner. [PDF]

PLoS Biol, 2023
Zhu M, Lv J, Wang W, Guo R, Zhong C, Antia A, Zeng Q, Li J, Liu Q, Zhou J, Zhu X, Fan B, Ding S, Li B.   +13 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses. [PDF]

Nat Commun
Xu Z, Jiang Z, Feng K, Zhang H, Shi C, Deng F, Wang H, Ning YJ.   +7 more
europepmc   +1 more source

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8. [PDF]

J Virol, 2023
Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q.   +17 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Identification of NECTIN1 as a novel restriction factor for flavivirus infection. [PDF]

mBio
Qi S, Sun C, Wang J, Wo L, Li Y, Wang C, Zhang Y, Bian H, Guo Y, Gao M, Wang M, Tang Y, Zhu Y, Xue F, Pang Q, Jiang Z, Yin X.   +16 more
europepmc   +1 more source

DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation. [PDF]

Viruses, 2022
Pallett MA, Lu Y, Smith GL.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2. [PDF]

Viruses
Torres C, Lagadec F, Basyuk E, Recordon-Pinson P, Métifiot M.   +4 more
europepmc   +1 more source

The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control. [PDF]

Autophagy, 2023
Saha B, Mandell MA.
europepmc   +1 more source