Results 41 to 50 of about 128,805 (254)

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +4 more sources

Chemosensitization of tumors by resveratrol [PDF]

Annals of the New York Academy of Sciences, 2011
Because tumors develop resistance to chemotherapeutic agents, the cancer research community continues to search for effective chemosensitizers. One promising possibility is to use dietary agents that sensitize tumors to the chemotherapeutics. In this review, we discuss that the use of resveratrol can sensitize tumor cells to chemotherapeutic agents ...
Subash C, Gupta, Ramaswamy, Kannappan, Simone, Reuter, Ji Hye, Kim, Bharat B, Aggarwal   +4 more
openaire   +2 more sources

Resveratrol and life extension [PDF]

Annals of the New York Academy of Sciences, 2011
Age is the most important risk factor for diseases affecting the Western world, and slowing age‐related degeneration would greatly improve the quality of human life. In rodents, caloric restriction (CR) extends lifespan by up to 50%. However, attempts to mimic the effects of CR pharmacologically have been limited by our poor understanding of the ...
Beamon, Agarwal, Joseph A, Baur
openaire   +2 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry [PDF]

, 2019
The reduction of sulfur dioxide in wine is a consumer’s demand, considering the allergic effects that may occur in people who are sensitive to it. Stilbenes are candidates of great interest for this purpose because of their antioxidant/antimicrobial ...
Cantos Villar, Emma, Medrano Padial, Concepción, Moreno Onorato, Francisco Javier, Pichardo Sánchez, Silvia, Puerto Rodríguez, María, Richard, Tristan   +5 more
core   +2 more sources

Synergistic Enhancement of Antioxidant Activity in Arbutus unedo Leaf Extract by Biological Fluids: Implications for Functional and Nutraceutical Applications

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This study examined the effect of biological fluids (saliva, blood plasma, and urine) on the antioxidant capacity of an aqueous extract derived from Arbutus unedo leaves. The extract displayed a concentration‐dependent reducing activity in the ferric reducing power assay (IC50 = 292 ± 7.54 µg/mL) and phosphomolybdenum assays (IC50 = 461.67 ± 4.
Idir Moualek, Hamdi Bendif, Karima Benarab, Giulio Lupidi, Fehmi Boufahja, Stefania Garzoli, Karim Houali   +6 more
wiley   +1 more source

Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]

, 2015
Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix, Bedi, Yudhishtar Singh, Chau, Jason, Choudhury, Mahua, Meruvu, Sunitha, Rucker, Robert, Zhang, Jian   +6 more
core   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli, Viktor Milkevych, Jette Feveile Young, Martin Krøyer Rasmussen   +3 more
wiley   +1 more source