Results 111 to 120 of about 94,066 (297)
KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons
Cytoskeleton, EarlyView.ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung +5 more
wiley +1 more source
Expression and function of GDNF family ligands and their receptors by human immune cells [PDF]
, 2004 GDNF (glial cell line-derived neurotrophic factor) und NTN (Neurturin), die zwei zuerst beschriebenen Liganden der GDNF-Familie, fungieren als Überlebens- und Entwicklungsfaktoren für definierte Populationen von zentralen und peripheren Neuronen.
Vargas-Leal, V. +2 more
core +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
Indian Journal of Endocrinology and MetabolismIntroduction: Limited data exist on the genetic profile of Familial primary hyperparathyroidism (FPHPT) in the Indian population. This study was conducted to determine the prevalence of targeted gene mutations in high-risk patients with PHPT.
Ajaz Qadir +8 more
doaj +1 more source
Inhibition of RET kinase activity for the treatment of thyroid cancer
, 2008 RET inhibitors in thyroid ...
SANTORO, MASSIMO
core
Abnormal Sustainability Reporting Tone and the Value Relevance of Accounting Fundamentals
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This study investigates whether and how abnormal sustainability reporting tone is associated with the firm's market value and conditions the value relevance of accounting fundamentals. Building on impression‐management theory, the value relevance literature, and recent advances in textual analysis, we focus on the discretionary component of ...
Alessandra Allini +3 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.Based on the 90 datasets, ERT and four optimization algorithms were used to build four hybrid models to predict the UCS of the backfill body. The SMA‐ERT model was the most effective model, and it can reliably guide the design of the backfill ratio parameters. Abstract This study analyzed the feasibility of using titanium (Ti) tailings as a backfilling
Weijun Liu, Zida Liu, Zhixiang Liu
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.This study proposes an exponentially‐constrained Gaussian mixture model (EcGMM) to quantify vertical fracture heterogeneity in stratified roof strata. The model integrates a piecewise exponential decay term capturing global stress dissipation with Gaussian components representing localized fracture intensification at lithological interfaces.
Huiqing Yuan +5 more
wiley +1 more source
, 2019 Sen. Joseph Dunn (Ret.) is a former California State Senator (1998-2006) and a Founder of UCI Law. He is the former Assistant Dean for External Relations at UCI Law and currently serves as Special Advisor to the Dean.https://scholarship.law.uci.edu ...
Dunn (Ret.), Sen. Joseph
core
Comparative Analysis of Metal Preloading Technologies in Batteries and Capacitors
EcoEnergy, EarlyView.Metal preloading strategies play an important role in efficient batteries and hybrid capacitors to compensate for the consumed metals at the first discharge. This article reviews recent progress in preloading technologies in lithium‐ion and other metal‐ion systems.
Xuexue Pan +3 more
wiley +1 more source