Results 51 to 60 of about 342,765 (293)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Remarks on the Compatibility of Opposite Arrows of Time
Entropy, 2005 : I argue that opposite arrows of time, while being logically possible, cannot realistically be assumed to exist during one and the same epoch of our universe.
H. D. Zeh
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Retardation in Nineteenth-Century Plays about Bureaucracy
СибСкриптBureaucracy was an extremely popular theme in Russian drama in the 1850s. It seems to be a promising direction for modern historical and literary studies, as well as narratology.
Anastasiia I. Lebedeva
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Management audit of the Department of Mental Retardation.
, 1990 Cover title: Management audit, Department of Mental Retardation.; "January 1990.
Connecticut. General Assembly. Legislative Program Review and Investigations Committee.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Pipeline direct from the state--Extra!
, 2007 Twice monthly.; Vol. 1, issue 1 (Feb. 14, 2007)-; An electronic publication reporting state and local issues and program initiatives of special interest to Ohio's MRDD community.
Ohio. Dept. of Mental Retardation and Developmental Disabilities.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source