Results 51 to 60 of about 259,684 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fatigue Damage Mechanism-Based Dependent Modeling With Stochastic Degradation and Random Shocks

IEEE Access, 2018
This paper proposes a dependent modeling method for reliability estimation of metal structures under constant amplitude loading and random shocks considering the nonlinear damage accumulation mechanism.
Dan Xu, Jiaolan He, Shaobo Sui, Shan Jiang, Wei Zhang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on the performance of nanoparticle-modified PVDF membrane in delaying membrane aging

Open Chemistry
With an emphasis on improving the membrane’s long-term durability and filtering efficiency, this study examines how well nanoparticle-modified polyvinylidene fluoride (PVDF) membranes perform in postponing membrane aging.
Lin Fuxing
doaj   +1 more source

Evaluation of tooth physiological characteristics based on PS-OCT

Journal of Innovative Optical Health Sciences
Accurate and early evaluation of dental physiological characteristics is essential for effective disease detection and management. Polarization-sensitive optical coherence tomography (PS-OCT) is a noninvasive high-resolution imaging technique that can ...
Songwen Xu, Weike Wang, Di Yang, Xiaoyi Zhao, Hao Liu, Yanmei Liang   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Comparison of depression with anxious distress and melancholic depression from the perspective of psychomotor disturbance

PCN Reports
Aim In the DSM‐5, it is specified that severe cases of major depressive disorder with anxious distress (ANXD) may be accompanied with motor agitation.
Yu Tamada, Takeshi Inoue, Atsushi Sekine, Hiroyuki Toda, Minoru Takeshima, Masaaki Sasaki, Yota Fujimura, Susumu Ohmae   +7 more
doaj   +1 more source

Influences of flocculant and retarder on solidification efficiency of cement in treatment of dredged mud slurry

Yantu gongcheng xuebao, 2019
It is usually necessary to build a working platform on the surface of the dumping site of dredged mud slurry for the purpose of rapid improvement of the dumping site so as to shorten the period of land occupation.
ZHANG Rong-jun 1, DONG Chao-qiang 1, ZHENG Jun-jie 1, LU Zhan 2
doaj   +1 more source