Results 61 to 70 of about 1,137 (129)

Subclinical Angioid Streaks with Pseudodrusen: A New Phenotype of Age-Related Macular Degeneration

Ophthalmology and Therapy, 2023
Introduction To describe subclinical angioid streaks (AS) as a frequent, peculiar age-related macular degeneration (AMD) phenotype, comparing features of eyes with subclinical AS with those of eyes with AMD without AS.
Riccardo Sacconi, Beatrice Tombolini, Ilaria Zucchiatti, Andrea Servillo, Matteo Menean, Giulio Falco Alessandrini, Lea Querques, Francesco Prascina, Peter Charbel Issa, Francesco Bandello, Giuseppe Querques   +10 more
doaj   +1 more source

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Acta Ophthalmologica, Volume 102, Issue 7, Page 759-772, November 2024.
Abstract Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent photoreceptors.
Juha M. T. Hyttinen, Ali Koskela, Janusz Blasiak, Kai Kaarniranta   +3 more
wiley   +1 more source

Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration

Life, 2021
Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major global cause of severe visual impairment. The development of an effective therapy to treat geographic atrophy, the predominant form of AMD, remains elusive due to
Monica L. Hu, Joel Quinn, Kanmin Xue
doaj   +1 more source

Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort

Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.
Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä, Leea Siintamo, Niko Kivinen, Nicholas Abrahamsson, Vesa Aaltonen, Kai Kaarniranta   +5 more
wiley   +1 more source

Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study

Acta Ophthalmologica, Volume 102, Issue 5, Page e813-e822, August 2024.
Abstract Purpose To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017.
Arnaud Sénéclauze, Mélanie Le Goff, Audrey Cougnard‐Grégoire, Jean‐François Korobelnik, Marie‐Bénédicte Rougier, Marie‐Noëlle Delyfer, Cécile Delcourt, Sarra Gattoussi   +7 more
wiley   +1 more source

Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD).
Marlene Saßmannshausen, Charlotte Behning, Ben Isselmann, Matthias Schmid, Robert P. Finger, Frank G. Holz, Steffen Schmitz-Valckenberg, Maximilian Pfau, MACUSTAR Consortium, Sarah Thiele   +9 more
doaj   +1 more source

Role of sleep-disordered breathing in age-related macular degeneration

BMJ Open Ophthalmology, 2023
Aims To examine the association between obstructive sleep apnoea (OSA) and age-related macular degeneration (AMD), and the subphenotype of AMD with reticular pseudodrusen (RPD).Methods Case–control study with 351 participants (211 AMD and 140 controls ...
Zhichao Wu, Chi D Luu, Robyn H Guymer, Palaniraj Rama Raj, Wendy Ying Fang, Carla Abbott, Matthew Naughton   +6 more
doaj   +1 more source

Choroidal structure determined by binarizing optical coherence tomography images in eyes with reticular pseudodrusen

Clinical Ophthalmology, 2017
Naonori Masuda, Masashi Kojima, Mariko Yamashita, Tomo Nishi, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Nara, Japan Purpose: To compare the choroidal structure beneath the macular area in eyes with reticular pseudodrusen (RPD ...
Masuda N, Kojima M, Yamashita M, Nishi T, Ogata N   +4 more
doaj  

ReticularNet: Automated Pixel-Level Segmentation of Reticular Pseudodrusen on Near-Infrared Reflectance Images by Deep Learning

Ophthalmology Science
Objective: Reticular pseudodrusen (RPD) represent an important biomarker in age-related macular degeneration (AMD) but are difficult to grade and often assessed only for presence or absence, without quantitative or spatial analysis of RPD burden.
Souvick Mukherjee, PhD, Dylan Wu, Leon von der Emde, MD, Emily Vance, MPH, Marco Ji, MD, Mehdi Emamverdi, MD, Tharindu De Silva, PhD, Alisa T. Thavikulwat, MD, Jayashree Kalpathy-Cramer, PhD, Amitha Domalpally, MD, PhD, Catherine A. Cukras, MD, PhD, Tiarnán D.L. Keenan, BM BCh, PhD   +11 more
doaj   +1 more source

Relationship between reticular pseudodrusen and choroidal thickness in intermediate age‐related macular degeneration: response [PDF]

, 2018
Chi YD Ho, Jia Jia Lek, Khin Zaw Aung, Myra B. McGuinness, Chi D. Luu, Robyn H. Guymer   +5 more
openalex   +1 more source