Results 71 to 80 of about 1,021 (141)

High risk does not guarantee high accuracy—Evaluating the prognostic accuracy of OCT biomarkers for predicting late AMD

Ophthalmic and Physiological Optics, Volume 45, Issue 6, Page 1293-1301, September 2025.
Abstract Purpose The translation of high‐risk biomarkers into accurate predictions of late age‐related macular degeneration (AMD) may be limited by biomarker prevalence, subjective identification and competing risks from concurrent biomarkers. This study evaluates the prognostic performance of key optical coherence tomography (OCT) biomarkers for ...
Matt Trinh, Rene Cheung, Judy Nam, David Ng, Lisa Nivison‐Smith, Angelica Ly   +5 more
wiley   +1 more source

Nocturnal hypoxia and age‐related macular degeneration

Clinical &Experimental Ophthalmology, Volume 52, Issue 9, Page 973-980, December 2024.
Abstract Background Nocturnal hypoxia is common, under‐diagnosed and is found in the same demographic at risk of age‐related macular degeneration (AMD). The objective of this study was to determine any association between nocturnal hypoxia and AMD, its severity, and the high‐risk sub‐phenotype of reticular pseudodrusen (RPD).
Attiqa Chaudhary, Carla J. Abbott, Zhichao Wu, Wendy Y. Fang, Palaniraj R. Raj, Matthew Naughton, Wilson J. Heriot, Robyn H. Guymer   +7 more
wiley   +1 more source

Subclinical Angioid Streaks with Pseudodrusen: A New Phenotype of Age-Related Macular Degeneration

Ophthalmology and Therapy, 2023
Introduction To describe subclinical angioid streaks (AS) as a frequent, peculiar age-related macular degeneration (AMD) phenotype, comparing features of eyes with subclinical AS with those of eyes with AMD without AS.
Riccardo Sacconi, Beatrice Tombolini, Ilaria Zucchiatti, Andrea Servillo, Matteo Menean, Giulio Falco Alessandrini, Lea Querques, Francesco Prascina, Peter Charbel Issa, Francesco Bandello, Giuseppe Querques   +10 more
doaj   +1 more source

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Acta Ophthalmologica, Volume 102, Issue 7, Page 759-772, November 2024.
Abstract Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent photoreceptors.
Juha M. T. Hyttinen, Ali Koskela, Janusz Blasiak, Kai Kaarniranta   +3 more
wiley   +1 more source

Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort

Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.
Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä, Leea Siintamo, Niko Kivinen, Nicholas Abrahamsson, Vesa Aaltonen, Kai Kaarniranta   +5 more
wiley   +1 more source

Reticular pseudodrusen load is associated with an increased risk of stroke

BMJ Open Ophthalmology
Background/aims Reticular pseudodrusen (RPD) are increasingly recognised as a distinct phenotype in the age-related macular degeneration (AMD) disease spectrum. This study investigates the association between RPD and cardiovascular outcomes, specifically
Adnan Tufail, Sandra Liakopoulos, Abraham Olvera-Barrios, Catherine Egan, Hagar Khalid, Roy Schwartz, Yanling Ouyang, Mahima Jhingan, Alasdair N. Warwick, Sumita Phatak, Coen de Vente, Philippe Valmaggia, Clara I. Sanchez-Guiterrez   +12 more
doaj   +1 more source

Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study

Acta Ophthalmologica, Volume 102, Issue 5, Page e813-e822, August 2024.
Abstract Purpose To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017.
Arnaud Sénéclauze, Mélanie Le Goff, Audrey Cougnard‐Grégoire, Jean‐François Korobelnik, Marie‐Bénédicte Rougier, Marie‐Noëlle Delyfer, Cécile Delcourt, Sarra Gattoussi   +7 more
wiley   +1 more source

Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration

BMC Ophthalmology, 2018
Background To identify novel biomarkers related to the pathogenesis of dry age-related macular degeneration (AMD), we adopted a human retinal pigment epithelial (RPE) cell culture model that mimics some features of dry AMD including the accumulation of ...
Je-Hyun Baek, Daehan Lim, Kyu Hyung Park, Jae-Byoung Chae, Hyoik Jang, Jonghyun Lee, Hyewon Chung   +6 more
doaj   +1 more source

Choroidal structure determined by binarizing optical coherence tomography images in eyes with reticular pseudodrusen

Clinical Ophthalmology, 2017
Naonori Masuda, Masashi Kojima, Mariko Yamashita, Tomo Nishi, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Nara, Japan Purpose: To compare the choroidal structure beneath the macular area in eyes with reticular pseudodrusen (RPD ...
Masuda N, Kojima M, Yamashita M, Nishi T, Ogata N   +4 more
doaj  

Selective reduction of the light peak-to-dark trough ratio in reticular macular disease: an electrooculography study

Frontiers in Neuroscience
PurposeTo compare electrooculogram (EOG) parameters between eyes with reticular macular disease (RMD) and eyes with early-to-intermediate age-related macular degeneration (AMD) without reticular pseudodrusen (RPD), and to assess whether RMD is associated
Lin Liu, Lu Cheng, Qi Ren, Qi Ren, Zhe Chu, Zhe Chu, Hao Cheng   +6 more
doaj   +1 more source