Results 21 to 30 of about 43,370 (248)
Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin +11 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
eLife, 2018 Co-opting the cellular machinery for protein production is a compulsory requirement for viruses. The Cricket Paralysis Virus employs an Internal Ribosomal Entry Site (CrPV-IRES) to express its structural genes in the late stage of infection.
Vera P Pisareva +2 more
doaj +1 more source
Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
The Maturation Rate of Reticulocytes [PDF]
Blood, 1960 Abstract An in vitro culture technic for the study of reticulocyte maturation was described. The method gave reproducible results and proved to be of value in the comparative study of reticulocyte maturation in blood disorders. By this method it was shown that variations in the reticulocyte maturation in vitro paralleled similar ...
M, BALDINI, I, PANNACCIULLI
openaire +2 more sources
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets
Cell Reports, 2016 Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from anucleate lineages by ribosome profiling and ...
Eric W. Mills +3 more
doaj +1 more source
Ranges for Reticulocyte Fractions and Reticulocyte Hemoglobin of Mongolian Donors
Central Asian Journal of Medical Sciences, 2017 Objectives: The goal of this study was to determine the performance of reticulocyte fractions and reticulocyte hemoglobin for early detection of iron deficiency and iron deficiency anemia among Mongolian blood donors. Methods: Blood samples were collected before and after blood donations and analyzed using a Sysmex XN- 2000 analyzer.
Purevjal Otgonbayar +3 more
openaire +2 more sources
American Journal of Hematology, EarlyView.ABSTRACT The RACE study (NCT02009747) compared horse antithymocyte globulin (hATG) plus cyclosporine A (CsA) ± eltrombopag as initial immunosuppressive treatment (IST) for severe aplastic anemia. Here we report the final 2‐year analysis of this prospective randomized phase III study.
Antonio M. Risitano +52 more
wiley +1 more source
IEEE AccessReticulocyte count is a routine blood test that can be an essential source of knowledge for medical doctors to diagnose and assess patients’ health condition.
Rabiah A. Al-Qudah, Ching Y. Suen
doaj +1 more source