Results 21 to 30 of about 45,498 (228)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES

eLife, 2018
Co-opting the cellular machinery for protein production is a compulsory requirement for viruses. The Cricket Paralysis Virus employs an Internal Ribosomal Entry Site (CrPV-IRES) to express its structural genes in the late stage of infection.
Vera P Pisareva, Andrey V Pisarev, Israel S Fernández   +2 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

The Maturation Rate of Reticulocytes [PDF]

Blood, 1960
Abstract An in vitro culture technic for the study of reticulocyte maturation was described. The method gave reproducible results and proved to be of value in the comparative study of reticulocyte maturation in blood disorders. By this method it was shown that variations in the reticulocyte maturation in vitro paralleled similar ...
M, BALDINI, I, PANNACCIULLI
openaire   +2 more sources

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Cell Reports, 2016
Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from anucleate lineages by ribosome profiling and ...
Eric W. Mills, Jamie Wangen, Rachel Green, Nicholas T. Ingolia   +3 more
doaj   +1 more source

Ranges for Reticulocyte Fractions and Reticulocyte Hemoglobin of Mongolian Donors

Central Asian Journal of Medical Sciences, 2017
Objectives: The goal of this study was to determine the performance of reticulocyte fractions and reticulocyte hemoglobin for early detection of iron deficiency and iron deficiency anemia among Mongolian blood donors. Methods: Blood samples were collected before and after blood donations and analyzed using a Sysmex XN- 2000 analyzer.
Purevjal Otgonbayar, Erdenebayar Namjil, Munkhbayarlakh Sonomjamts, Odgerel Tsogbadrakh   +3 more
openaire   +2 more sources

Differences Ret-He, Reticulocyte, and Hemoglobin Levels Pre and Post Administration of Erythropoietin in Patients With Chronic Kidney Disease Undergoing Hemodialysis [PDF]

Modern Medicine
Background: Chronic Kidney Disease (CKD) patients undergoing hemodialysis usually undergo anemia condition. Calculation of hemoglobin and other hematological parameters such as Ret-he (Reticulocyte Hemoglobin) and reticulocytes along with Glomerulus ...
Eko Hendry LUKITO, Purwanto ADIPIRENO, Edward Kurnia Setiawan LIMIJADI   +2 more
doaj   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

A Data-Centric Approach to Investigate the Feasibility of Utilizing Animal Medical Data as a Solution for Human Medical Data Scarcity

IEEE Access
Reticulocyte count is a routine blood test that can be an essential source of knowledge for medical doctors to diagnose and assess patients’ health condition.
Rabiah A. Al-Qudah, Ching Y. Suen
doaj   +1 more source