Results 41 to 50 of about 43,370 (248)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Determination of reference ranges for immature platelet and reticulocyte fractions and reticulocyte hemoglobin equivalent

Revista Brasileira de Hematologia e Hemoterapia
Introduction: The immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content.
Iuri Vicente Camargo Morkis, Mariela Granero Farias, Luciana Scotti   +2 more
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Optimization of Reflex Testing Rules on the Sysmex XN‐9100 Automated Hematology Line Improves Efficiency and Reduces Repeat Testing in Different Work Areas

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract summarizes a workflow‐based Reflex rule optimization for the Sysmex XN‐9100 automated hematology line. A total of 78,364 routine complete blood count samples were analyzed by middleware simulation. The optimized strategy differentiated initial from follow‐up visit samples, incorporated 7‐day historical fluctuation thresholds ...
Lianhui Yu, Min Zhang, Jianying Li, Ping Deng, Haoting Zhan, Wei Wu   +5 more
wiley   +1 more source

Research Note: Reticulocytes and related erythroid atypia of ducks—indicators of stress or pathology?

Poultry Science
: Two kinds of reticulocytes, and atypical erythroid cells, were found in the blood of apparently healthy ducks with Wright–Giemsa (W–G) stain. The reticulin of network-type examples (nRtc) is of a large complex (3-D) form.
Paul F. Cotter
doaj   +1 more source

A preterm neonate with infantile liver failure syndrome 1 due to leucyl‐tRNA synthetase 1 gene (LARS1) mutations with a histopathologic phenotype of neonatal hemochromatosis

JPGN Reports, EarlyView.
Abstract We report a case of a premature, growth‐restricted female infant with feeding intolerance and coagulopathy, treated initially for sepsis, who progressed to neonatal acute liver failure and end‐stage hepatic encephalopathy after a prolonged hospitalization with extensive diagnostic evaluation, and was found by autopsy to have histopathologic ...
Adrienne Bruder, Naomi Laventhal, Raja Rabah, Jacqueline Meadow   +3 more
wiley   +1 more source

A high reticulocyte count is a risk factor for the onset of metabolic dysfunction-associated steatotic liver disease: Cross-sectional and prospective studies of data of 310,091 individuals from the UK Biobank

Frontiers in Pharmacology
Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a considerable health risk. Nevertheless, its risk factors are not thoroughly comprehended, and the association between the reticulocyte count and MASLD remains ...
Peng-Cheng Ma, Peng-Cheng Ma, Peng-Cheng Ma, Qi-Mei Li, Rui-Ning Li, Chang Hong, Hao Cui, Zi-Yong Zhang, Yan Li, Lu-Shan Xiao, Lu-Shan Xiao, Hong Zhu, Lin Zeng, Lin Zeng, Jun Xu, Jun Xu, Jun Xu, Wei-Nan Lai, Li Liu, Li Liu   +19 more
doaj   +1 more source

Reference range evaluation of complete blood count parameters with emphasis on newer research parameters on the complete blood count analyzer Sysmex XE-2100

Indian Journal of Pathology and Microbiology, 2013
Since the advent of automation in the field of hematological cell counters there has been a constant refinement of the technology and increase in the number of newer parameters available on CBC analysers.
Kunal K Sehgal, Dadu Tina, Urmi Choksey, Reeta J Dalal, Khodaiji J Shanaz   +4 more
doaj   +1 more source

Utility of Faster R-CNN in methodological comparison and evaluation of reticulocytes

Frontiers in Physiology
ObjectiveThe purpose of this study was to evaluate the methodological comparison of reticulocytes by using the intelligent learning system Faster R-CNN, a set of reticulocyte image detection systems developed using deep neural networks.MethodsWe selected
Shengli Sun, Geng Wang, Binyao Zhang, Fei Wang, Wei Wu   +4 more
doaj   +1 more source