Results 51 to 60 of about 48,191 (295)

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Reticulocyte evaluation in alpha(+)-thalassemia

, 2015
Although it is almost certain that alpha(+)-thalassemia protects against malaria, the mechanisms for that are still unknown. It has been suggested that an increased number of young circulating red blood cells in alpha(+)-thalassemic children, as a result
Krugner, F, Grotto, H Z W, Zaccariotto, TR, Costa, F F, Rosim, ET, Sonati, MF, Grotto, HZW, Rosim, E T, Sonati, M F, Costa, FF, Zaccariotto, T R   +10 more
core   +2 more sources

Allometric scaling of reticulocyte count.

, 2013
We plot the logarithm of reticulocyte count of a given mammal as a function of the logarithm of its mass (in gram). Plotted data correspond to a total of 40 mammal species with masses ranging over 6 orders of magnitude, from voles to whales.
Jorge M. Pacheco (67599), David Dingli (45713)   +1 more
core   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Reference intervals for reticulocyte count and derived reticulocyte parameters in a cohort of healthy adults

Introduction Reticulocyte count and novel derived parameters provide insight into the effectiveness of erythropoiesis and may be useful tools in the classification and diagnosis of anemias.
Martínez‐Novillo González, Mercedes, Posada Franco, Yolanda, García‐Álvarez, Ana, Contera‐Raposo, Rocío, Martínez-Novillo González, Mercedes, Sanz‐Casla, María Teresa, Hernández‐Álvarez, Elena, Serrano‐García, Irene   +7 more
core   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Research Note: Reticulocytes and related erythroid atypia of ducks—indicators of stress or pathology?

Poultry Science
: Two kinds of reticulocytes, and atypical erythroid cells, were found in the blood of apparently healthy ducks with Wright–Giemsa (W–G) stain. The reticulin of network-type examples (nRtc) is of a large complex (3-D) form.
Paul F. Cotter
doaj   +1 more source

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

Drug Testing and Analysis, EarlyView.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder, Corentin Schlechten, Claudia Mumenthaler, Olivier Salamin, Tiia Kuuranne, Thomas Christian Bonne, Jonathan Graae, Henrik Sørensen, Nikolai B. Nordsborg, Nicolas Leuenberger   +9 more
wiley   +1 more source

A high reticulocyte count is a risk factor for the onset of metabolic dysfunction-associated steatotic liver disease: Cross-sectional and prospective studies of data of 310,091 individuals from the UK Biobank

Frontiers in Pharmacology
Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a considerable health risk. Nevertheless, its risk factors are not thoroughly comprehended, and the association between the reticulocyte count and MASLD remains ...
Peng-Cheng Ma, Peng-Cheng Ma, Peng-Cheng Ma, Qi-Mei Li, Rui-Ning Li, Chang Hong, Hao Cui, Zi-Yong Zhang, Yan Li, Lu-Shan Xiao, Lu-Shan Xiao, Hong Zhu, Lin Zeng, Lin Zeng, Jun Xu, Jun Xu, Jun Xu, Wei-Nan Lai, Li Liu, Li Liu   +19 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source