Results 181 to 190 of about 26,590 (287)

A Personalized, Rate‐of‐Rise (ROR)–Driven Model to Optimize Red Cell Exchange Interval in Chronic Sickle Cell Management

Journal of Clinical Apheresis, Volume 41, Issue 4, August 2026.
ABSTRACT Chronic automated red blood cell exchange (RCE) is a cornerstone therapy for preventing sickle cell disease (SCD)‐related complications, particularly stroke and recurrent vaso‐occlusive crises. Current scheduling commonly relies on uniform empirical intervals of 3–6 weeks and does not account for substantial inter‐patient variability in ...
Menatalla Nadim, Austin Choi, Nicholas Parisi, Yamac Akgun   +3 more
wiley   +1 more source

Comprehensive Phenotypic and Proteomic Analyses of Human Reticulocyte Maturation. [PDF]

Blood Red Cells Iron
Leduc M, Papoin J, Yan H, Le Gall M, El Nemer W, Hillyer C, Gallagher PG, Gautier EF, Mohandas N, Blanc L.   +9 more
europepmc   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease. [PDF]

J Clin Invest
Sezaki M, Li T, Pan M, Wang Z, Bai J, Horowitz JG, Xu JZ, Huang G.   +7 more
europepmc   +1 more source

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger, Lilla Lankovics, István Dudás, Tünde Bárkai, Zsófia Szász, Mirjam Balbisi, Anthony Yan‐Tang Wu, Krisztina V. Vukman, Kelsey Fletcher, Attila Csomos, Zoltán Mucsi, Edina Bugyik, Csaba Cserép, Ádám Dénes, Szilvia Bősze, Lilla Turiák, Charles Pin‐Kuang Lai, Edit I. Buzás, Tamás Visnovitz   +18 more
wiley   +1 more source

Luspatercept for the treatment of transfusion-dependent non-severe aplastic anemia. [PDF]

Ann Hematol
Jia X, Zheng R, Hong Y, Ge H, Shen Y, Zhou Y, Yang X, Wu D.   +7 more
europepmc   +1 more source

Association of Frailty With Transfusions, Hospitalizations, and Survival in Patients With Myelodysplastic Syndrome Initiating Hypomethylating Agents

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Introduction Prognostic scoring systems in MDS lack functional status measures. We sought to evaluate the influence of frailty on overall survival and care utilization in a national cohort. We conducted a retrospective study in the US Veterans Affairs Healthcare System of patients with MDS initiated on hypomethylating agents (HMAs) from 2004 ...
Anahid Hamparsumian, Jennifer La, Mayuri Dharne, Gary Gilbert, Mary T. Brophy, Nhan V. Do, Dae Hyun Kim, Jane A. Driver, Nathanael R. Fillmore, Clark DuMontier   +9 more
wiley   +1 more source

The reticulocyte restriction: invasion ligand RBP1a of Plasmodium vivax targets human TfR1, prohibitin-2, and basigin. [PDF]

Front Cell Infect Microbiol
Molina-Franky J, Röth D, Ararat-Sarria M, Patarroyo MA, Kalkum M.   +4 more
europepmc   +1 more source

Evaluation of The Use of Hydroxyurea in Treating Children With Sickle Cell Anemia in Central Africa's Rural Area

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Background Sickle cell anemia (SCA) is highly prevalent in Central Africa. This disease causes severe manifestations in children, requiring treatment. Hydroxyurea (HU) is currently the most effective treatment for SCA. We evaluated the use of HU in children living in rural Central Africa.
Gloire Mbayabo, Paul Lumbala Kabuyi, Mamy Ngole, Aimé Lumaka, Valerie Race, Gert Matthijs, Tite Mikobi Minga, Koenraad Devriendt, Chris Van Geet, Prosper Tshilobo Lukusa   +9 more
wiley   +1 more source

Stage-specific disruption of erythropoiesis leads to anemia in newly diagnosed multiple myeloma patients. [PDF]

Front Cell Dev Biol
Wang S, Fu W, Chen C, Kong H, Liu S, Guo J, Li D, Ma R, Liu D, Chen H, Qu X, Li M, An C, Zhao H, Zhu Z.   +14 more
europepmc   +1 more source