Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan +2 more
wiley +1 more source
Primary rib haemangiosarcoma in two dogs
Abstract Primary rib haemangiosarcoma is an uncommon neoplasm, with only 24 cases reported since 1974. We describe the clinical presentation, diagnostic findings, and outcomes of two dogs with this condition. One dog was younger than 4 years old. Clinical signs included a palpable thoracic mass, lethargy, hyporexia, dyspnoea, pale mucous membranes and ...
Jocosa T. Yasenchack +4 more
wiley +1 more source
A novel isoform of tensin-1 promotes actin filament assembly for efficient erythroblast enucleation. [PDF]
Ghosh A +7 more
europepmc +1 more source
Pyometra in an African wild dog (Lycaon pictus)
Abstract Reports of pyometra in wild canids such as African wild dogs remain scarce. Management of pyometra in geriatric individuals with concurrent anaemia presents a distinctive clinical challenge. A 16.1 kg rescued geriatric female African wild dog (Lycaon pictus) presented to Greens Zoological Rescue and Rehabilitation Centre, Jamnagar, with ...
Nitin Tambe +4 more
wiley +1 more source
Pyruvate Kinase Deficiency: Markedly Decreased Reticulocyte PK Activity and Limited Specificity of the PK/HK Ratio. [PDF]
Koleva L +9 more
europepmc +1 more source
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter +19 more
wiley +1 more source
Mechanism of Babao Dan on fluorouracil-induced bone marrow suppression and T cell immune disorder through MAPK pathway. [PDF]
Yan S +11 more
europepmc +1 more source
Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed +11 more
wiley +1 more source
The GLOBE Trial: Efficacy and Safety of L-Glutamine Plus Hydroxyurea Versus Hydroxyurea Alone in Sickle Cell Anemia - A Double-Blind, Randomized Study [PDF]
Shakibazad N +4 more
europepmc +1 more source

