Results 181 to 190 of about 570,903 (309)

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

VEGFR2-dependent VEGFR3 expression leads to CXCL1/2 and CXCR2 induction in the development of retinal neovascularization. [PDF]

Angiogenesis
Yadavalli CS, Kumar R, Govatati S, Rao GN.   +3 more
europepmc   +1 more source

Multifunctional Vertical Bulk‐Heterojunction Transistors With Amorphous GaOx for Neuromorphic Perception‐to‐Decision

Advanced Science, EarlyView.
A multifunctional vertical bulk‐heterojunction transistor (MVBT) with amorphous GaOx integrates four functionalities within a single neuromorphic device. Gate‐source operation enables 254 nm deep‐ultraviolet sensing and threshold neuronal firing, whereas three‐terminal operation supports broadband UV–vis‐NIR synaptic functions and bias‐controlled ...
Jinkui Si, Qiong Zhuang, Rengjian Yu, Junling Zhou, Lan Yang, Changjie Zhou, Huili Zhu, Minshuai Wang, Xiaomei Cai, Qiubao Lin, Wangying Xu, Shuqiong Lan, Huipeng Chen   +12 more
wiley   +1 more source

Presumed non-inflammatory bilateral peripapillary subretinal fibrosis in adolescent patients. [PDF]

BMC Ophthalmol
Celik Dulger S, Teke MY.
europepmc   +1 more source

Disrupted Top‐Down Modulation as a Mechanism of Impaired Multisensory Processing in Autistic Children

Advanced Science, EarlyView.
In this work, we show that multisensory integration in autistic children is characterized by attenuated ERP responses and α‐band desynchronization, together with reduced theta‐band communication between parieto‐occipital and frontal regions. The intermediate neural profile observed in unaffected siblings raises the possibility that altered cortical ...
Theo Vanneau, John J. Foxe, Shlomit Beker, Sophie Molholm   +3 more
wiley   +1 more source

ACUTE BILATERAL RETINAL AND CHOROIDAL DETACHMENT-A CASE REPORT. [PDF]

Retin Cases Brief Rep
Vienne-Jumeau A, Toutée A, Zegrari S, Jamart C, Audo I, Paques M, Mrejen S.   +6 more
europepmc   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source

The Translational Value of Preclinical Research: Lessons from More Than Forty Years of Retinal Research. [PDF]

Biomedicines
Bagnoli P.
europepmc   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Diabetic Retinal Disease Onset and Progression During Established Semaglutide or Tirzepatide Treatment: A Retrospective Comparative Cohort Study With a Descriptive Regional Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Review. [PDF]

Cureus
Muhsen J.
europepmc   +1 more source