Results 91 to 100 of about 39,677 (234)

The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision [PDF]

, 2017
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation.
Arden, Bauer, Baylor, Berridge, Bronckers, Bronckers, Calvert, Corbo, Dizhoor, Fain, Gorczyca, Herzog, Hu, Hughes, Ingram, Jalloul, Kang, Korenbrot, Lamason, Lamb, Le, Li, Li, Makino, Mattapallil, Matthews, Matveev, Mendez, Miller, Nakatani, Neuillé, Nikonov, Nikonov, Palczewski, Parry, Picones, Poetsch, Prieto, Prinsen, Pugh, Rebrik, Reiländer, Riazuddin, Sakurai, Sakurai, Sakurai, Sampath, Sampath, Schnetkamp, Schwarzer, Schwarzer, Seymen, Shichida, Shirato, Smith, Stephan, Sulem, Szél, Tachibanaki, Takemoto, Tomizuka, Tsoi, Vinberg, Vinberg, Vinberg, Wang, Wang, Winkler, Yau, Yau   +69 more
core   +2 more sources

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Exploring AKAPs in visual signaling

Frontiers in Molecular Neuroscience
The complex nature of the retina demands well-organized signaling to uphold signal accuracy and avoid interference, a critical aspect in handling a variety of visual stimuli.
Julia Tomczak, Joanna Mackiewicz, Malwina Lisek, Aleksandra Kaluza, Tomasz Boczek   +4 more
doaj   +1 more source

The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]

, 2019
Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core  

Novel rodent models for macular research [PDF]

, 2010
Background: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Huber, Gesine, Heynen, Severin, Imsand, Coni, vom Hagen, Franziska, Muehlfriedel, Regine, Tanimoto, Naoyuki, Feng, Yuxi, Hammes, Hans-Peter, Grimm, Christian, Peichl, Leo, Seeliger, Mathias W., Beck, Susanne Christiane   +11 more
core   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Systematic analysis of Hyperpolarization-activated and Cyclic Nucleotide-gated (HCN) channels in photoreceptors and bipolar cells of the rat retina. [PDF]

, 2004
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels were studied in the rat retina. The expression pattern of the four HCN channel isoforms HCN1 - 4 was studied using immunocytochemistry with isoform-specific antibodies and confocal ...
Ivanova, Elena
core  

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy

BMC Ophthalmology, 2012
Background Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in retinal damage.
Wang Yujuan, Abu-Asab Mones S, Li Wei, Aronow Mary E, Singh Arun D, Chan Chi-Chao   +5 more
doaj   +1 more source