Results 81 to 90 of about 39,677 (234)

Decreased Expression of DREAM Promotes the Degeneration of Retinal Neurons. [PDF]

PLoS ONE, 2015
The intrinsic mechanisms that promote the degeneration of retinal ganglion cells (RGCs) following the activation of N-Methyl-D-aspartic acid-type glutamate receptors (NMDARs) are unclear.
Shravan Chintala, Mei Cheng, Xiao Zhang
doaj   +1 more source

Local processing in neurites of VGluT3- expressing amacrine cells differentially organizes visual information [PDF]

, 2017
Neurons receive synaptic inputs on extensive neurite arbors. How information is organized across arbors and how local processing in neurites contributes to circuit function is mostly unknown.
Amthor, Arnson, Asari, Behrens, Bloomfield, Borghuis, Churchland, Crook, Debanne, Demb, Diamond, Ding, Euler, Franke, Greene, Grienberger, Grimes, Grimes, Grimes, Harvey, Haverkamp, Haverkamp, Helmstaedter, Jacoby, Johnson, Kim, Kim, Kleindienst, Krishnaswamy, Le Martelot, Lee, Lee, Leonardo, London, Losonczy, MacNeil, Madisen, Madisen, Marc, Olveczky, Park, Purgert, Schindelin, Schwartz, Shekhar, Tien, Tien, Vlasits, Vlasits, Wang, Wang, Yonehara, Yoshida, Yuste, Zhang   +54 more
core   +2 more sources

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Melanopsin mediates retrograde visual signaling in the retina.

PLoS ONE, 2012
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic ...
Dao-Qi Zhang, Michael A Belenky, Patricia J Sollars, Gary E Pickard, Douglas G McMahon   +4 more
doaj   +1 more source

Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.

PLoS ONE, 2013
The paraneoplastic retinopathies (PRs) are a group of eye diseases characterized by a sudden and progressive dysfunction of the retina caused by an antibody against a protein in a neoplasm. Evidence has been obtained that the transient receptor potential
Shinji Ueno, Koji M Nishiguchi, Hidetoshi Tanioka, Atsushi Enomoto, Takashi Yamanouchi, Mineo Kondo, Testuhiro R Yasuma, Shunsuke Yasuda, Noriyuki Kuno, Masahide Takahashi, Hiroko Terasaki   +10 more
doaj   +1 more source

Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

Acta Neuropathologica Communications, 2021
Accumulation of misfolded host proteins is central to neuropathogenesis of numerous human brain diseases including prion and prion-like diseases. Neurons of retina are also affected by these diseases.
James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro   +4 more
doaj   +1 more source

Reduced Retinal Degeneration in an Oxidative Stress Organ Culture Model through an iNOS-Inhibitor

Biology, 2021
In retinal organ cultures, H2O2 can be used to simulate oxidative stress, which plays a role in the development of several retinal diseases including glaucoma.
Ana M. Mueller-Buehl, Teresa Tsai, José Hurst, Carsten Theiss, Laura Peters, Lisa Hofmann, Fenja Herms, Sandra Kuehn, Sven Schnichels, Stephanie C. Joachim   +9 more
doaj   +1 more source

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

Retina‐Inspired Bi‐Based Terahertz Photonic Neuromorphic Devices

Advanced Science, EarlyView.
Combined with effective band alignment and substrate engineering, bismuth materials are introduced to form terahertz photonic bio‐inspired devices with picosecond short‐term plasticity to enable multi‐scene visual perception. Thus obtained hardware through the terahertz optical neural network (THz‐ONN) demonstrates high recognition accuracy, providing ...
Pujing Zhang, Donggang Xie, Longyu Shi, Mengyuan Wang, Huiwen Shi, Yu Wu, Menglei Li, Guangwei She, Peijie Wang, Wensheng Shi, Cunlin Zhang, Kuijuan Jin, Guozhen Yang, Qingli Zhou, Chen Ge   +14 more
wiley   +1 more source

Illuminating the Intracellular World: Breakthroughs in Nanoscale Optoelectronics

Advanced Electronic Materials, EarlyView.
This perspective explores optoelectronic biointerfaces spanning macroscale flexible devices to nanoscale intracellular systems, emphasizing their integration across dimensions. It examines capacitive, Faradaic, and photothermal mechanisms that enable light‐driven control of cellular activity and highlights key material and design challenges in ...
Tania Assaf, Menahem Y. Rotenberg
wiley   +1 more source