Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells
Stem Cell Research, 2018 During development, multipotent progenitors undergo temporally-restricted differentiation into post-mitotic retinal cells; however, the mechanisms of progenitor division that occurs during retinogenesis remain controversial.
Saeed Khalili +12 more
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Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2012 Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood.
Miao Chen, Ke Wang, Bin Lin
doaj +6 more sources
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration [PDF]
Life Science Alliance, 2020 This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Ema Ozaki +10 more
doaj +5 more sources
Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice [PDF]
Cell Communication and SignalingBackground X-linked juvenile retinoschisis (XLRS) is a hereditary retinal disorder caused by mutations in the RS1 gene that leads to the formation of cavities in the inner nuclear layer (INL) and progressive vision loss, characterized by a ...
Jin Young Yang +10 more
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Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine. [PDF]
PLoS ONE, 2015 PURPOSE:RGC-5 cells undergo differentiation into a neuronal phenotype with low concentrations of staurosporine. Although the RGC-5 cell line was initially thought to be of retinal ganglion cell origin, recent evidence suggests that the RGC-5 line could ...
Alex F Thompson +3 more
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Cell-specific DNA methylation patterns of retina-specific genes. [PDF]
PLoS ONE, 2012 Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation.
Shannath L Merbs +6 more
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AAV9 targets cone photoreceptors in the nonhuman primate retina. [PDF]
PLoS ONE, 2013 Transduction of retinal pigment epithelial cells with an adeno-associated viral vector (AAV) based on serotype 2 has partially corrected retinal blindness in Leber congenital amaurosis type 2.
Luk H Vandenberghe +7 more
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Universality of Form: The Case of Retinal Cone Photoreceptor Mosaics
Entropy, 2023 Cone photoreceptor cells are wavelength-sensitive neurons in the retinas of vertebrate eyes and are responsible for color vision. The spatial distribution of these nerve cells is commonly referred to as the cone photoreceptor mosaic.
Alireza Beygi
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Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model
Molecular Therapy: Nucleic Acids, 2023 Blindness in Bardet-Biedl syndrome (BBS) is caused by dysfunction and loss of photoreceptor cells in the retina. BBS10, mutations of which account for approximately 21% of all BBS cases, encodes a chaperonin protein indispensable for the assembly of the ...
Ying Hsu +12 more
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Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.
PLoS Genetics, 2023 In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, which
Bernadett Bosze +4 more
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