Results 21 to 30 of about 19,866 (162)

661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies

Frontiers in Genetics, 2019
The retina contains several ciliated cell types, including the retinal pigment epithelium (RPE) and photoreceptor cells. The photoreceptor cilium is one of the most highly modified sensory cilia in the human body.
Gabrielle Wheway, Gabrielle Wheway, Gabrielle Wheway, Liliya Nazlamova, Liliya Nazlamova, Liliya Nazlamova, Dann Turner, Stephen Cross   +7 more
doaj   +1 more source

RbpjCell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina [PDF]

The Journal of Neuroscience, 2009
Vertebrate retinal progenitor cells (RPCs) are pluripotent, but pass through competence states that progressively restrict their developmental potential (Cepko et al., 1996; Livesey and Cepko, 2001; Cayouette et al., 2006). In the rodent eye, seven retinal cell classes differentiate in overlapping waves, with RGCs, cone photoreceptors, horizontals, and
Amy N, Riesenberg, Zhenyi, Liu, Raphael, Kopan, Nadean L, Brown   +3 more
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A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors

PLoS Biology, 2011
Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse.
Jackman, Skyler L., Babai, Norbert, Chambers, James J., Thoreson, Wallace B., Kramer, Richard H.   +4 more
openaire   +5 more sources

Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea [PDF]

Cell Stem Cell, 2022
High-definition vision in humans and nonhuman primates is initiated by cone photoreceptors located within a specialized region of the retina called the fovea. Foveal cone death is the ultimate cause of central blindness in numerous retinal dystrophies, including macular degenerative diseases.
Aindrila Saha, Elizabeth Capowski, Maria A. Fernandez Zepeda, Emma C. Nelson, David M. Gamm, Raunak Sinha   +5 more
openaire   +2 more sources

Temporal Progression of Retinal Progenitor Cell Identity: Implications in Cell Replacement Therapies

Frontiers in Neural Circuits, 2017
Retinal degenerative diseases, which lead to the death of rod and cone photoreceptor cells, are the leading cause of inherited vision loss worldwide. Induced pluripotent or embryonic stem cells (iPSCs/ESCs) have been proposed as a possible source of new ...
Awais Javed, Awais Javed, Michel Cayouette, Michel Cayouette, Michel Cayouette, Michel Cayouette   +5 more
doaj   +1 more source

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors [PDF]

Stem Cell Reports, 2017
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision.
Gonzalez-Cordero, Anai, Kruczek, Kamil, Naeem, Arifa, Fernando, Milan, Kloc, Magdalena, Ribeiro, Joana, Goh, Debbie, Duran, Yanai, Blackford, Samuel J.I., Abelleira-Hervas, Laura, Sampson, Robert D., Shum, Ian O., Branch, Matthew J., Gardner, Peter J., Sowden, Jane C., Bainbridge, James W.B., Smith, Alexander J., West, Emma L., Pearson, Rachael A., Ali, Robin R.   +19 more
openaire   +7 more sources

Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish.

PLoS ONE, 2012
In non-mammalian vertebrates, the pineal gland functions as the central pacemaker that regulates the circadian rhythms of animal behavior and physiology. We generated a transgenic zebrafish line [Tg(Gnat2:gal4-VP16/UAS:nfsB-mCherry)] in which the E. coli
Xinle Li, Jake Montgomery, Wesley Cheng, Jung Hyun Noh, David R Hyde, Lei Li   +5 more
doaj   +1 more source

Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration. [PDF]

PLoS ONE, 2011
Retinitis pigmentosa (RP) is a group of photoreceptor degenerative disorders that lead to loss of vision. Typically, rod photoreceptors degenerate first, resulting in loss of night and peripheral vision.
Xin Xia, Yiwen Li, Deqiang Huang, Zhengying Wang, Lingyu Luo, Ying Song, Lian Zhao, Rong Wen   +7 more
doaj   +1 more source

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

Cell Reports, 2021
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment.
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali   +19 more
doaj   +1 more source

Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity [PDF]

Cell Reports, 2018
In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photoreceptor pathway remain poorly understood. Here, we found that Lrit1, a leucine-rich transmembrane protein, localizes to
Akiko Ueno, Yoshihiro Omori, Yuko Sugita, Satoshi Watanabe, Taro Chaya, Takashi Kozuka, Tetsuo Kon, Satoyo Yoshida, Kenji Matsushita, Ryusuke Kuwahara, Naoko Kajimura, Yasushi Okada, Takahisa Furukawa   +12 more
openaire   +3 more sources