Results 31 to 40 of about 19,866 (162)
Adaptation in cone photoreceptors contributes to an unexpected insensitivity of On parasol retinal ganglion cells to spatial structure in natural images [PDF]
eLife, 2021 Abstract Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions.
Maxwell H Turner +3 more
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Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration
Frontiers in Neuroscience, 2022 The retina is an important visual organ, which is responsible for receiving light signals and transmitting them to the optic nerve center step by step.
Meng Zhao +7 more
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Scientific Reports, 2017 A photoreceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone photoreceptor cells has been described earlier. However, these cells can be differentiated into neuronal cells. Here, we report that this cell line
Zuberwasim Sayyad +3 more
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Frontiers in Cellular Neuroscience, 2023 Photoreceptors possess a highly specialized primary cilium containing expanded ciliary membrane discs called the outer segment. The photoreceptor cilium is essential for the maintenance of the outer segment, and pathogenic variants in more than 50 cilia ...
Kei Takahashi +4 more
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Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. [PDF]
PLoS ONE, 2013 We sought to characterize the regenerated cells, if any, when photoreceptor ablation was mostly limited to a particular cone subtype. This allowed us to uniquely assess whether the remaining cells influence specification of regenerating photoreceptors ...
Brittany Fraser +3 more
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Frontiers in Genetics, 2022 Retinitis pigmentosa and related photoreceptor dystrophies (RPRPD) are rare retinal diseases caused by hereditary gene mutations resulting in photoreceptor death, followed by vision loss.
Galina Dvoriantchikova +3 more
doaj +1 more source
Expression of Cone-Photoreceptor–Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic Mice [PDF]
Investigative Opthalmology & Visual Science, 2004 To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate its photoreceptor origin.The 661W cells were cloned from retinal tumors of a transgenic mouse line that expresses the simian virus (SV) 40 T antigen under control of the human interphotoreceptor retinol-binding protein (IRBP ...
Elaine, Tan +5 more
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A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. [PDF]
PLoS Genetics, 2005 Rod and cone photoreceptors subserve vision under dim and bright light conditions, respectively. The differences in their function are thought to stem from their different gene expression patterns, morphologies, and synaptic connectivities. In this study,
Joseph C Corbo, Constance L Cepko
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Role of microglial cells in photoreceptor degeneration
Neural Regeneration Research, 2019 Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world. They comprise various diseases, but retinitis pigmentosa is the most frequently observed. Retinitis pigmentosa is commonly limited to the eye,
Johnny Di Pierdomenico +4 more
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NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration [PDF]
Human Molecular Genetics, 2016 The molecular signaling leading to cell death in hereditary neurological diseases such as retinal degeneration is incompletely understood. Previous neuroprotective studies have focused on apoptotic pathways; however, incomplete suppression of cell death with apoptosis inhibitors suggests that other mechanisms are at play. Here, we report that different
Ishaq A, Viringipurampeer +8 more
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